Browsing FAS Scholarly Articles by Title
Now showing items 7119-7138 of 18292
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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
(2013)The RNA-programmable Cas9 endonuclease cleaves double-stranded DNA at sites complementary to a 20-base-pair guide RNA. The Cas9 system has been used to modify genomes in multiple cells and organisms, demonstrating its ... -
High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling
(American Chemical Society, 2015)Cryptococcus neoformans is one of the most important human fungal pathogens; however, no new therapies have been developed in over 50 years. Fungicidal activity is crucially important for an effective anticryptococal agent ... -
A High-Throughput Screening Approach to Discovering Good Forms of Biologically Inspired Visual Representation
(Public Library of Science, 2009)While many models of biological object recognition share a common set of “broad-stroke” properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ... -
High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria
(Public Library of Science, 2013)Bacterial cell wall components have been previously used as infection biomarkers detectable by antibodies. However, it is possible that the surface of the Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis ... -
High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics
(Public Library of Science, 2015)The importance of single-cell level data is increasingly appreciated, and significant advances in this direction have been made in recent years. Common to these technologies is the need to physically segregate individual ... -
High-velocity Line Forming Regions in the Type Ia Supernova 2009ig
(American Astronomical Society, 2013)We report measurements and analysis of high-velocity (HVF) (>20,000 km s(-1)) and photospheric absorption features in a series of spectra of the Type Ia supernova (SN) 2009ig obtained between -14 days and +13 days with ... -
Higher Education and Authoritarian Resilience: The Case of China, Past and Present
(Harvard-Yenching Institute, 2017-03-20)Why are some autocracies more durable than others? In analyzing the institutional mechanisms that sustain authoritarian regimes, and help to explain their historical longevity as well as their persistence in the 21st ... -
Higher Education Reform in China and India: The Role of the State
(Havard-Yenching Institute, 2015) -
Higher nimbers in pawn endgames on large chessboards
(Cambridge University Press, 2002)We answer a question posed in [Elkies 1996] by constructing a class of pawn endgames on mXn boards that show the Nimbers <i>*k</i> for many large <k>k</k>. We do this by modifying and generalizing T.R. Dawson’s “pawns game” ... -
Higher Order Contributions to the 21 cm Power Spectrum
(American Astronomical Society, 2007) -
Higher Spins in AdS and Twistorial Holography
(Springer Verlag, 2011)In this paper we simplify and extend previous work on three-point functions in Vasiliev's higher spin gauge theory in \(AdS_4\). We work in a gauge in which the space-time dependence of Vasiliev's master fields is gauged ... -
Higher-Level Metazoan Relationships: Recent Progress and Remaining Questions
(Springer Science + Business Media, 2011)Metazoa comprises 35–40 phyla that include some 1.3 million described species. Phylogenetic analyses of metazoan interrelationships have progressed in the past two decades from those based on morphology and/or targeted-gene ... -
Higher-order Behavioral Contracts for Distributed Components
(2015)Inspired by the Design by Contract paradigm, we introduce CONSUL, a contract system for distributed components. CONSUL monitors distributed components at run time with higher-order behavioral contracts. Contract monitoring ... -
Highlights and discoveries from the Chandra X-ray Observatory
(IOP Publishing, 2014)Within 40 years of the detection of the first extrasolar X-ray source in 1962,NASA's Chandra X-ray Observatory has achieved an increase in sensitivity of 10 orders of magnitude, comparable to the gain in going from naked-eye ... -
Highly compliant transparent electrodes
(AIP Publishing, 2012)Adaptive optical devices based on electric field induced deformation of dielectricelastomers require transparent and highly compliant electrodes to conform to large shape changes. Electrical, optical, and actuation properties ... -
Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies
(BioMed Central, 2008)Background: With over 20 parapatric races differing in their warningly colored wing patterns, the butterfly Heliconius erato provides a fascinating example of an adaptive radiation. Together with matching races of its ... -
A highly conspicuous mineralized composite photonic architecture in the translucent shell of the blue-rayed limpet
(Nature Pub. Group, 2015)Many species rely on diverse selections of entirely organic photonic structures for the manipulation of light and the display of striking colours. Here we report the discovery of a mineralized hierarchical photonic ... -
Highly deformable actuators made of dielectric elastomers clamped by rigid rings
(AIP Publishing, 2014)In the nascent field of soft machines, soft materials are used to create devices that actuate robots, sense environment, monitor health, and harvest energy. The soft materials undergo large deformation in response to ... -
The Highly Deuterated Chemistry of the Early Universe
(IOP Publishing, 2011)A comprehensive chemistry of the highly deuterated species D2, D+ 2, D2H+, and D+ 3 in the early universe is presented. Fractional abundances for each are calculated as a function of redshift z in the recombination era. ... -
Highly directive current distributions: General theory
(American Physical Society, 1998)A theoretical scheme for studying the properties of localized, monochromatic, and highly directive classical current distributions in two and three dimensions is formulated and analyzed. For continuous current distributions, ...