Now showing items 1-3 of 3

    • Epigenomics and Chromatin Dynamics 

      Akopian, Veronika; Chan, Michelle; Clement, Kendell; Galonska, Christina; Gifford, Casey; Lehtola, Elizabeth; Liao, Jing; Samavarchi-Tehrani, Payman; Sindhu, Camille; Smith, Zachary D; Tsankov, Alexander; Webster, Jamie Orme; Zhang, Yingying; Ziller, Michael Johannes; Meissner, Alexander (BioMed Central, 2012)
      A report of the 'Joint Keystone Symposium on Epigenomics and Chromatin Dynamics', Keystone, Colorado, 17-22 January 2012. This year's Joint Keystone Symposium on Epigenomics and Chromatin Dynamics was one of the largest ...
    • Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling 

      Boyle, Patrick; Clement, Kendell; Gu, Hongcang; Smith, Zachary D; Ziller, Michael Johannes; Fostel, Jennifer L; Holmes, Laurie; Meldrim, Jim; Kelley, Fontina; Gnirke, Andreas; Meissner, Alexander (BioMed Central, 2012)
      Sequencing-based approaches have led to new insights about DNA methylation. While many different techniques for genome-scale mapping of DNA methylation have been employed, throughput has been a key limitation for most. To ...
    • Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia 

      Landau, Dan Avi; Clement, Kendell; Ziller, Michael Johannes; Boyle, Patrick; Fan, Jean; Gu, Hongcang; Stevenson, Kristen; Sougnez, Carrie; Wang, Lili; Li, Shuqiang; Kotliar, Dylan; Zhang, Wandi; Ghandi, Mahmoud; Garraway, Levi Alexander; Fernandes, Stacey M.; Livak, Kenneth J.; Gabriel, Stacey; Gnirke, Andreas; Lander, Eric Steven; Brown, Jennifer Ruth; Neuberg, Donna S.; Kharchenko, Peter Vasili; Hacohen, Nir; Getz, Gad A; Meissner, Alexander; Wu, Catherine J. (Elsevier BV, 2014)
      Intratumoral heterogeneity plays a critical role in tumor evolution. To define the contribution of DNA methylation to heterogeneity within tumors, we performed genome-scale bisulfite sequencing of 104 primary chronic ...