Now showing items 1-20 of 253

    • Acceptance of Mobile Technology by Older Adults: A Preliminary Study 

      Kim, Sunyoung; Gajos, Krzysztof Z; Muller, Michael; Grosz, Barbara J. (2016)
      Mobile technologies offer the potential for enhanced healthcare, especially by supporting self-management of chronic care. For these technologies to impact chronic care, they need to work for older adults, because the ...
    • Accurate Path Integration in Continuous Attractor Network Models of Grid Cells 

      Burak, Yoram; Fiete, Ila R. (Public Library of Science, 2009)
      Grid cells in the rat entorhinal cortex display strikingly regular firing responses to the animal's position in 2-D space and have been hypothesized to form the neural substrate for dead-reckoning. However, errors ...
    • Activation of the Immune Response is a Key Feature of Aging in Mice 

      Brink, Thore C.; Regenbrecht, Christian; Demetrius, Lloyd A.; Lehrach, Hans; Adjaye, James (Springer Netherlands, 2009)
      The process of aging is complex involving numerous factors centered on transcriptional changes with advanced age. This study was aimed at elucidating mechanisms involved in mouse aging by conducting both gene expression ...
    • Adaptive Use of Bubble Wrap for Storing Liquid Samples and Performing Analytical Assays 

      Bwambok, David K.; Christodouleas, Dionysios; Morin, Stephen A.; Lange, Heiko; Phillips, Scott T.; Whitesides, George McClelland (American Chemical Society (ACS), 2014)
      This paper demonstrates that the gas-filled compartments in the packing material commonly called “bubble wrap” can be repurposed in resource-limited regions as containers to store liquid samples, and to perform bioanalyses. ...
    • Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging 

      Brink, Thore C.; Demetrius, Lloyd A.; Lehrach, Hans; Adjaye, James (Springer Netherlands, 2008)
      Individual differences in the rate of aging are determined by the efficiency with which an organism transforms resources into metabolic energy thus maintaining the homeostatic condition of its cells and tissues. This ...
    • Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes 

      Demogines, Ann; East, Alysia M.; Lee, Ji-Hoon; Grossman, Sharon Rachel; Sabeti, Pardis Christine; Paull, Tanya T.; Sawyer, Sara L. (Public Library of Science, 2010)
      In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little ...
    • Antidumping: The Third Rail of Trade Policy 

      Mankiw, N; Swagel, Phillip (Council on Foreign Relations, 2005)
      Although few U.S. politicians will admit it, antidumping policy has strayed far from its original purpose of guarding against predatory foreign firms. It is now little more than an excuse for a few powerful industries to ...
    • Application of Protein Microarrays for Multiplexed Detection of Antibodies to Tumor Antigens in Breast Cancer 

      Anderson, Karen S.; Ramachandran, Niroshan; Wong, Jessica; Raphael, Jacob V.; Hainsworth, Eugenie; Demirkan, Gokhan; Cramer, Daniel William; Aronzon, Dina; Hodi, Frank Stephen; Harris, Lyndsay; Logvinenko, Tanya; LaBaer, Joshua (American Chemical Society (ACS), 2008)
      There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveillance. This continual monitoring, by both the innate and the adaptive immune systems, recognizes changes in protein expression, ...
    • Applying GIS Methods to Public Health Research at Harvard University 

      Blossom, Jeffrey C.; Finkelstein, Julia; Guan, Wendy; Burns, Bonnie A. (Informa UK Limited, 2011)
      The Center for Geographic Analysis (CGA) at Harvard University supports research and teaching that relies on geographic information. This includes supporting geographic analysis for public health research at Harvard. This ...
    • Are Testers Also Admitters? Comparing Emergency Physician Resource Utilization and Admitting Practices 

      Hodgson, Nicole; Saghafian, Souroush; Mi, Lanyu; Buras, Matthew; Katz, Eric; Pines, Jesse; Sanchez, Leon; Silvers, Scott; Maher, Steven; Traub, Stephen (Elsevier BV, 2018-10)
      Objective: To describe the relationship between emergency department resource utilization and admission rate at the level of the individual physician. Methods: Retrospective observational study of physician resource ...
    • Are you Going to Do That? Contingent-Payment Mechanisms to Improve Coordination 

      Ma, Hongyao; Meir, Reshef; Parkes, David C.; Zou, James (2015)
      In this extended abstract, we consider simple coordination problems, such as allocating the right to use a shared sports facility in a way that maximizes its usage, or picking the time of a meeting in a way that maximizes ...
    • Association Between Trajectories of Statin Adherence and Subsequent Cardiovascular Events 

      Franklin, Jessica Myers; Krumme, Alexis Ann; Tong, Angela Y.; Shrank, William; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh (Wiley-Blackwell, 2015)
      PURPOSE: Trajectory models have been shown to (1) identify groups of patients with similar patterns of medication filling behavior and (2) summarize the trajectory, the average adherence in each group over time. However, ...
    • Association pattern discovery via theme dictionary models 

      Deng, Ke; Geng, Zhi; Liu, Jun (Wiley-Blackwell, 2013)
      Discovering patterns from a set of text or, more generally, categorical data is an important problem in many disciplines such as biomedical research, linguistics, artificial intelligence and sociology. We consider here the ...
    • Availability and utilization of cardiovascular fixed-dose combination drugs in the United States 

      Wang, Bo; Choudhry, Niteesh Kumar; Gagne, Joshua J; Landon, Joan; Kesselheim, Aaron Seth (Elsevier BV, 2015)
      BACKGROUND: Solid clinical evidence supports the effectiveness and safety of multiple drugs in treating diabetes, dyslipidemia, and hypertension, and numerous fixed-dose combination products (FDCs) containing such drugs ...
    • AXIS: Generating Explanations at Scale with Learnersourcing and Machine Learning 

      Williams, Joseph Jay; Kim, Juho; Rafferty, Anna; Maldonado, Samuel; Gajos, Krzysztof Z; Lasecki, Walter; Heffernan, Neil (2016)
      While explanations may help people learn by providing information about why an answer is correct, many problems on online platforms lack high-quality explanations. This paper presents AXIS (Adaptive eXplanation Improvement ...
    • Band alignment of SnS/Zn(O,S) heterojunctions in SnS thin film solar cells 

      Sun, Leizhi; Haight, Richard; Sinsermsuksakul, Prasert; Bok Kim, Sang; Park, Helen Hejin; Gordon, Roy Gerald (American Institute of Physics, 2013)
      Band alignment is critical to the performance of heterojunction thin film solar cells. In this letter, we report band alignment studies of SnS/Zn(O,S) heterojunctions with various compositions of Zn(O,S). Valence band ...
    • The Big and the Small: Challenges of Imaging the Brain's Circuits 

      Lichtman, Jeff; Denk, W. (American Association for the Advancement of Science (AAAS), 2011)
      The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function ...
    • Biologically-Inspired Control for Multi-Agent Self-Adaptive Tasks 

      Yu, Chih-Han; Nagpal, Radhika (American Association for Artificial Intelligence (AAAI) Press, 2010)
      Decentralized agent groups typically require complex mechanisms to accomplish coordinated tasks. In contrast, biological systems can achieve intelligent group behaviors with each agent performing simple sensing and actions. ...
    • Bound States of Guided Matter Waves: An Atom and a Charged Wire 

      Hau, Lene Vestergaard; Burns, Michael M.; Golovchenko, Jene A. (American Physical Society, 1992)
      We argue that it is possible to bind a neutral atom in stable orbits around a wire charged by a time-varying sinusoidal voltage. Both classical and quantum-mechanical theories for this system are discussed, and a unified ...