Browsing FAS Scholarly Articles by Keyword "Cell Signaling"

Now showing items 1-4 of 4

    • Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling 

      Estrada, Javier; Andrew, Natalie; Gibson, Daniel; Chang, Frederick; Gnad, Florian; Gunawardena, Jeremy (Public Library of Science, 2016)
      The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell’s environment. This suggests that the external environment may be harnessed to interrogate the cell’s ...

    • Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells 

      Ho, Catherine M. K.; Donovan-Banfield, I’ah Z.; Tan, Li; Zhang, Tinghu; Gray, Nathanael S.; Strang, Blair L. (Public Library of Science, 2016)
      Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor ...

    • An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology 

      Fernandes de Abreu, Diana Andrea; Caballero, Antonio; Fardel, Pascal; Stroustrup, Nicholas; Chen, Zhunan; Lee, KyungHwa; Keyes, William D.; Nash, Zachary M.; López-Moyado, Isaac F.; Vaggi, Federico; Cornils, Astrid; Regenass, Martin; Neagu, Anca; Ostojic, Ivan; Liu, Chang; Cho, Yongmin; Sifoglu, Deniz; Shen, Yu; Fontana, Walter; Lu, Hang; Csikasz-Nagy, Attila; Murphy, Coleen T.; Antebi, Adam; Blanc, Eric; Apfeld, Javier; Zhang, Yun; Alcedo, Joy; Ch'ng, QueeLim (Public Library of Science, 2014)
      Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse ...

    • Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development 

      Perdigoto, Carolina N.; Dauber, Katherine L.; Bar, Carmit; Tsai, Pai-Chi; Valdes, Victor J.; Cohen, Idan; Santoriello, Francis J.; Zhao, Dejian; Zheng, Deyou; Hsu, Ya-Chieh; Ezhkova, Elena (Public Library of Science, 2016)
      An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes. Here, we have uncovered ...