Browsing FAS Scholarly Articles by Keyword "Ebola virus"

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    • In vivo Ebola virus infection leads to a strong innate response in circulating immune cells 

      Caballero, Ignacio S.; Honko, Anna N.; Gire, Stephen K.; Winnicki, Sarah M.; Melé, Marta; Gerhardinger, Chiara; Lin, Aaron E.; Rinn, John L.; Sabeti, Pardis C.; Hensley, Lisa E.; Connor, John H. (BioMed Central, 2016)
      Background: Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is thought to become dysregulated, but the mechanisms ...

    • Unbiased Deep Sequencing of RNA Viruses from Clinical Samples 

      Matranga, Christian B.; Gladden-Young, Adrianne; Qu, James; Winnicki, Sarah; Nosamiefan, Dolo; Levin, Joshua Z.; Sabeti, Pardis C. (MyJove Corporation, 2016)
      Here we outline a next-generation RNA sequencing protocol that enables de novo assemblies and intra-host variant calls of viral genomes collected from clinical and biological sources. The method is unbiased and universal; ...