Browsing FAS Scholarly Articles by Keyword "Endocrine System"

Now showing items 1-3 of 3

    • An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology 

      Fernandes de Abreu, Diana Andrea; Caballero, Antonio; Fardel, Pascal; Stroustrup, Nicholas; Chen, Zhunan; Lee, KyungHwa; Keyes, William D.; Nash, Zachary M.; López-Moyado, Isaac F.; Vaggi, Federico; Cornils, Astrid; Regenass, Martin; Neagu, Anca; Ostojic, Ivan; Liu, Chang; Cho, Yongmin; Sifoglu, Deniz; Shen, Yu; Fontana, Walter; Lu, Hang; Csikasz-Nagy, Attila; Murphy, Coleen T.; Antebi, Adam; Blanc, Eric; Apfeld, Javier; Zhang, Yun; Alcedo, Joy; Ch'ng, QueeLim (Public Library of Science, 2014)
      Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse ...

    • MARIS: Method for Analyzing RNA following Intracellular Sorting 

      Hrvatin, Siniša; Deng, Francis; O'Donnell, Charles W.; Gifford, David K.; Melton, Douglas A. (Public Library of Science, 2014)
      Transcriptional profiling is a key technique in the study of cell biology that is limited by the availability of reagents to uniquely identify specific cell types and isolate high quality RNA from them. We report a Method ...

    • Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy 

      Cox, Aaron R.; Barrandon, Ornella; Cai, Erica P.; Rios, Jacqueline S.; Chavez, Julia; Bonnyman, Claire W.; Lam, Carol J.; Yi, Peng; Melton, Douglas A.; Kushner, Jake A. (Public Library of Science, 2016)
      The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies ...