Browsing FAS Scholarly Articles by Keyword "Epistasis"
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Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance
(Public Library of Science, 2016)The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to ... -
The competition between simple and complex evolutionary trajectories in asexual populations
(BioMed Central, 2015)Background: On rugged fitness landscapes where sign epistasis is common, adaptation can often involve either individually beneficial “uphill” mutations or more complex mutational trajectories involving fitness valleys or ...