Browsing FAS Scholarly Articles by Keyword "depression"
Now showing items 1-20 of 24
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Acute Stress Selectively Reduces Reward Sensitivity
(Frontiers Research Foundation, 2013)Stress may promote the onset of psychopathology by disrupting reward processing. However, the extent to which stress impairs reward processing, rather than incentive processing more generally, is unclear. To evaluate the ... -
A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
(Frontiers Media SA, 2009)Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism ... -
Dependent, but not Perfectionistic, Dysfunctional Attitudes Predict Worsened Mood and Appraisals after Emotional Support from a Romantic Partner
(Frontiers Media S.A., 2016)Background: Receiving emotional support from a romantic partner often leads to emotional costs via negative appraisals about the self and one's relationship, but it is unclear whether certain individuals are more susceptible ... -
Dissociable Recruitment of Rostral Anterior Cingulate and Inferior Frontal Cortex in Emotional Response Inhibition
(Academic Press, 2008)The integrity of decision-making under emotionally evocative circumstances is critical to navigating complex environments, and dysfunctions in these processes may play an important role in the emergence and maintenance of ... -
Effect of 2 Psychotherapies on Depression and Disease Activity in Pediatric Crohn's Disease
(Lippincott Williams & Wilkins, 2015)Background: Crohn's disease (CD) is associated with depression. It is unclear if psychosocial interventions offer benefit for depressive symptoms during active CD. In this secondary analysis of a larger study of treating ... -
Enhanced Negative Feedback Responses in Remitted Depression
(Lippincott Williams & Wilkins, 2008)Major depressive disorder (MDD)is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction. MDD patients exhibit enhanced electrophysiological responses to negative internal ... -
Euthymic Patients with Bipolar Disorder Show Decreased Reward Learning in a Probabilistic Reward Task
(Elsevier, 2008)Background: Bipolar disorder (BPD) features cycling mood states ranging from depression to mania with intermittent phases of euthymia. Bipolar disorder subjects often show excessive goal-directed and pleasure-seeking ... -
Factors that distinguish college students with depressive symptoms with and without suicidal thoughts
(Springer, 2013)BACKGROUND Suicide among college students is a significant public health concern. Although suicidality is linked to depression, not all depressed college students experience suicidal ideation (SI). The primary aim of ... -
The Heritability of Hedonic Capacity and Perceived Stress: A Twin Study Evaluation of Candidate Depressive Phenotypes
(Cambridge University Press, 2009)Background. Anhedonia and stress sensitivity have been identified as promising depressive phenotypes. Research suggests that stress-induced anhedonia is a possible mechanism underlying the association between stress and ... -
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
(Springer Nature, 2017)Background: Depressive disorders are the second-leading cause of global disability, and an area of increasing focus in international health efforts. We describe a community health worker (CHW) program rolled out in a ... -
Implicit Depression and Hopelessness in Remitted Depressed Individuals
(Elsevier Science, 2008)Cognitive theories of depression posit that automatically activated cognitive schemas, including negative thoughts about the self and the future, predispose individuals to develop depressive disorders. However, prior ... -
Increased Perceived Stress is Associated with Blunted Hedonic Capacity: Potential Implications for Depression Research
(Elsevier Science, 2007)Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity, in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards ... -
Individual Differences in Amygdala-Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk
(Society for Neuroscience, 2012)Individual differences in affective and social processes may arise from variability in amygdala-medial prefrontal (mPFC) circuitry and related genetic heterogeneity. To explore this possibility in humans, we examined the ... -
Mixed Effects of Deep Brain Stimulation on Depressive Symptomatology in Parkinson’s Disease: A Review of Randomized Clinical Trials
(Frontiers Media S.A., 2014)Although ~50% of patients with Parkinson’s disease (PD) experience depression, treatment for this important and debilitating comorbidity is relatively understudied. Deep brain stimulation (DBS) has been increasingly utilized ... -
Modular Approach to Therapy for Anxiety, Depression, Trauma, or Conduct Problems in outpatient child and adolescent mental health services in New Zealand: study protocol for a randomized controlled trial
(BioMed Central, 2015)Background: Mental health disorders are common and disabling for young people because of the potential to disrupt key developmental tasks. Implementation of evidence-based psychosocial therapies in New Zealand is limited, ... -
Predicting suicide attempts in depressed adolescents: Clarifying the role of disinhibition and childhood sexual abuse
(Elsevier BV, 2015)Background Suicide is the second leading cause of death among adolescents, and depressed youth are six times more likely to make suicide attempts as compared to non-depressed adolescents. The present study examined the ... -
Racial identity and depression among African American women.
(American Psychological Association (APA), 2010)This study examines direct, interactive, and indirect effects of racial identity and depression in a sample of 379 African American women. Results indicated that higher racial private and public regard were associated with ... -
Reduced Hedonic Capacity in Major Depressive Disorder: Evidence from a Probabilistic Reward Task
(Elsevier, 2008)Objective: Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the ... -
Response Conflict and Frontocingulate Dysfunction in Unmedicated Participants with Major Depression
(Pergamon Press, 2008)Individuals with major depressive disorder (MDD) often exhibit impaired executive function, particularly in experimental tasks that involve response conflict and require adaptive behavioral adjustments. Prior research ... -
The Role of the Nucleus Accumbens and Rostral Anterior Cingulate Cortex in Anhedonia: Integration of Resting EEG, fMRI, and Volumetric Techniques
(Elsevier, 2006)Anhedonia, the reduced propensity to experience pleasure, is a promising endo-- phenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used ...