Browsing FAS Scholarly Articles by Keyword "developmental biology"

Now showing items 1-15 of 15

    • All β Cells Contribute Equally to Islet Growth and Maintenance 

      Brennand, Kristen; Huangfu, Danwei; Melton, Douglas (Public Library of Science, 2007)
      In healthy adult mice, the β cell population is not maintained by stem cells but instead by the replication of differentiated β cells. It is not known, however, whether all cells contribute equally to growth and maintenance, ...

    • Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord 

      Huang, Peng; Xiong, Fengzhu; Megason, Sean; Schier, Alexander F (Public Library of Science, 2012)
      During the development of the spinal cord, proliferative neural progenitors differentiate into postmitotic neurons with distinct fates. How cells switch from progenitor states to differentiated fates is poorly understood. ...

    • The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing 

      Huang, Yun; Pastor, William Abraham; Shen, Yinghua; Tahiliani, Mamta V.; Liu, David Ruchien; Rao, Anjana; Liu, Jun (Public Library of Science, 2010)
      Background: We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons. The methylation status of ...

    • A Careful Look at Binding Site Reorganization in the even-skipped Enhancers of Drosophila and Sepsids 

      Hare, Emily E.; Peterson, Brant K.; Eisen, Michael B. (Public Library of Science, 2008)

    • The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros 

      Selleck, Rori; Song, Huai-Dong; Song, Anhua; Thisse, Bernard; Thisse, Christine; Mullins, Mary; Wingert, Rebecca Ann; Yu, Jingyi; Chen, Zhu; Zhou, Yi; McMahon, Andrew P.; Davidson, Alan J. (Public Library of Science, 2007)
      Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood. ...

    • Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis 

      Wanat, Jennifer J.; Kim, Keun Pill; Koszul, Romain; Zanders, Sarah; Weiner, Beth Meryl; Kleckner, Nancy Elizabeth; Alani, Eric; Lichten, Michael Nicholas (Public Library of Science, 2008)
      Chromosome movements are a general feature of mid-prophase of meiosis. In budding yeast, meiotic chromosomes exhibit dynamic movements, led by nuclear envelope (NE)-associated telomeres, throughout the zygotene and pachytene ...

    • Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response 

      Zhong, Mei; Niu, Wei; Lu, Zhi John; Sarov, Mihail; Janette, Judith; Raha, Debasish; Sheaffer, Karyn L.; Lam, Hugo Y. K.; Preston, Elicia; Slightham, Cindie; Hillier, LaDeana W.; Agarwal, Ashish; Auerbach, Raymond; Hyman, Anthony A.; Gerstein, Mark; Kim, Stuart K.; Waterston, Robert H.; Reinke, Valerie; Snyder, Michael; Murray, John I.; Mango, Susan; Brock, Trisha Jane (Public Library of Science, 2010)
      Transcription factors are key components of regulatory networks that control development, as well as the response to environmental stimuli. We have established an experimental pipeline in Caenorhabditis elegans that permits ...

    • Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains 

      Rheinbay, Esther; Endoh, Mitsuhiro; Mikkelsen, Tarjei S.; Nusbaum, Chad; Xie, Xiaohui; Adli, Mazhar; Kasif, Simon; Ptaszek, Leon M.; Koseki, Haruhiko; van Steensel, Bas; Ku, Manching; Koche, Richard Patrick; Mendenhall, Eric M; Presser, Aviva; Chi, Andrew S.; Cowan, Chad A.; Lander, Eric Steven; Bernstein, Bradley E. (Public Library of Science, 2008)
      In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ...

    • Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells 

      Forsberg, E. Camilla; Passegué, Emmanuelle; Prohaska, Susan S.; Wagers, Amy Jo; Koeva, Martina; Stuart, Joshua M.; Weissman, Irving L. (Public Library of Science, 2010)
      Hematopoietic stem cells (HSC) are rare, multipotent cells capable of generating all specialized cells of the blood system. Appropriate regulation of HSC quiescence is thought to be crucial to maintain their lifelong ...

    • Order and Stochastic Dynamics in Drosophila Planar Cell Polarity 

      Burak, Yoram; Shraiman, Boris I. (Public Library of Science, 2009)
      Cells in the wing blade of Drosophila melanogaster exhibit an in-plane polarization causing distal orientation of hairs. Establishment of the Planar Cell Polarity (PCP) involves intercellular interactions as well as a ...

    • Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe 

      Dearborn, Richard E.; Dai, Yong; Reed, Brian; Karian, Tamar; Gray, Jessica; Kunes, Samuel M. (Public Library of Science, 2012)
      Receptors of the Eph family of tyrosine kinases and their Ephrin ligands are involved in developmental processes as diverse as angiogenesis, axon guidance and cell migration. However, our understanding of the Eph signaling ...

    • Reversible Disassembly of the Actin Cytoskeleton Improves the Survival Rate and Developmental Competence of Cryopreserved Mouse Oocytes 

      Hosu, Basarab Gabriel; Mullen, Steven F.; Critser, John K.; Forgacs, Gabor; Steinhardt, Richard (Public Library of Science, 2008)
      Effective cryopreservation of oocytes is critically needed in many areas of human reproductive medicine and basic science, such as stem cell research. Currently, oocyte cryopreservation has a low success rate. The goal of ...

    • Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation 

      Hare, Emily E.; Peterson, Brant K.; Iyer, Venky N.; Meier, Rudolf; Eisen, Michael B. (Public Library of Science, 2008)
      The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. However, we demonstrate here that ...

    • A Sex-Ratio Meiotic Drive System in Drosophila Simulans. I: An Autosomal Suppressor 

      Tao, Yun; Masly, John P; Araripe, Luciana Ordunha; Ke, Yeyan; Hartl, Daniel L. (Public Library of Science, 2007)
      Sex ratio distortion (sex-ratio for short) has been reported in numerous species such as Drosophila, where distortion can readily be detected in experimental crosses, but the molecular mechanisms remain elusive. Here we ...

    • Systematic Analysis of Pleiotropy in C. elegans Early Embryogenesis 

      Zou, Lihua; Sriswasdi, Sira; Ross, Brian D; Missiuro, Patrycja V.; Liu, Jun; Ge, Hui; Sidow, Arend (Public Library of Science, 2008)
      Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. ...