Browsing FAS Scholarly Articles by Keyword "experimental biophysical methods"
Now showing items 1-2 of 2
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Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
(Public Library of Science, 2008)Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical ... -
Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
(Public Library of Science, 2009)Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As ...