Now showing items 1-2 of 2

    • Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport 

      Sherman, David Joseph; Lazarus, Michael B.; Murphy, Lea; Liu, Charles Xin; Kahne, Suzanne Walker; Ruiz, Natividad; Kahne, Daniel (Proceedings of the National Academy of Sciences, 2014)
      Gram-negative bacteria contain an unusual outer membrane that prevents the entry of most currently available antibiotics. This membrane contains a complex glycolipid, LPS, on the exterior. It is not understood how such a ...
    • Inhibition of the βbarrel assembly machine by a peptide that binds BamD 

      Hagan, Christine Lepicier; Wzorek, Joseph Stanley; Kahne, Daniel (Proceedings of the National Academy of Sciences, 2015)
      The protein complex that assembles integral membrane β-barrel proteins in the outer membranes of Gram-negative bacteria is an attractive target in the development of new antibiotics. This complex, the β-barrel assembly ...