Now showing items 1-11 of 11

    • Adaptive Locomotor Behavior in Larval Zebrafish 

      Portugues, Ruben; Engert, Florian (Frontiers Media SA, 2011)
      In this study we report that larval zebrafish display adaptive locomotor output that can be driven by unexpected visual feedback. We develop a new assay that addresses visuomotor integration in restrained larval zebrafish. ...
    • Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling 

      Lin, Michelle I; Price, Emily N; Boatman, Sonja; Hagedorn, Elliott J; Trompouki, Eirini; Satishchandran, Sruthi; Carspecken, Charles W; Uong, Audrey; DiBiase, Anthony; Yang, Song; Canver, Matthew C; Dahlberg, Ann; Lu, Zhigang; Zhang, Cheng Cheng; Orkin, Stuart H; Bernstein, Irwin D; Aster, Jon C; White, Richard M; Zon, Leonard I (eLife Sciences Publications, Ltd, 2015)
      Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show ...
    • Challenging zebrafish escape responses by increasing water viscosity 

      Danos, N.; Lauder, George V. (The Company of Biologists, 2012)
      Escape responses of fishes have long been studied as a model locomotor behavior in which hypothesized maximal or nearmaximal muscle power output is used to generate rapid body bending. In this paper we present the results ...
    • The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain 

      Bianco, Isaac; Wilson, Stephen W. (The Royal Society, 2009)
      The dorsal diencephalon, or epithalamus, contains the bilaterally paired habenular nuclei and the pineal complex. The habenulae form part of the dorsal diencephalic conduction (DDC) system, a highly conserved pathway found ...
    • Mlck1a Is Expressed in Zebrafish Thrombocytes and Is an Essential Component of Thrombus Formation 

      Tournoij, E.; Weber, G. J.; Akkerman, J. W. N.; De Groot, P. G.; Zon, Leonard Ira; Moll, F. L.; Schulte-Merker, S. (Wiley-Blackwell, 2009)
      Background: We have used the advantages of the zebrafish model system to demonstrate which of the vertebrate Myosin Light Chain Kinase (MLCK) genes is expressed in thrombocytes and important for thrombus formation. Methods ...
    • Monitoring Neural Activity with Bioluminescence during Natural Behavior 

      Naumann, Eva Aimable; Kampff, Adam R.; Prober, David A.; Schier, Alexander F; Engert, Florian (Nature Publishing Group, 2010)
      Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the activity ...
    • Navigational strategies underlying phototaxis in larval zebrafish 

      Chen, Xiuye; Engert, Florian (Frontiers Media S.A., 2014)
      Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. Using larval zebrafish, we study the temporal component of phototaxis, which is defined as ...
    • Prey Capture Behavior Evoked by Simple Visual Stimuli in Larval Zebrafish 

      Bianco, Isaac; Kampff, Adam R.; Engert, Florian (Frontiers Media SA, 2011)
      Understanding how the nervous system recognizes salient stimuli in the environment and selects and executes the appropriate behavioral responses is a fundamental question in systems neuroscience. To facilitate the ...
    • Response to Nodal morphogen gradient is determined by the kinetics of target gene induction 

      Dubrulle, Julien; Jordan, Benjamin M; Akhmetova, Laila; Farrell, Jeffrey A; Kim, Seok-Hyung; Solnica-Krezel, Lilianna; Schier, Alexander F (eLife Sciences Publications, Ltd, 2015)
      Morphogen gradients expose cells to different signal concentrations and induce target genes with different ranges of expression. To determine how the Nodal morphogen gradient induces distinct gene expression patterns during ...
    • Two-photon calcium imaging during fictive navigation in virtual environments 

      Ahrens, Misha B.; Huang, Kuo Hua; Narayan, Sujatha; Mensh, Brett D.; Engert, Florian (Frontiers Media S.A., 2013)
      A full understanding of nervous system function requires recording from large populations of neurons during naturalistic behaviors. Here we enable paralyzed larval zebrafish to fictively navigate two-dimensional virtual ...
    • A zebrafish model of conditional targeted podocyte ablation and regeneration 

      Huang, Jianmin; Mckee, Mary; Huang, Hong Dong; Xiang, Alice; Davidson, Alan J; Lu, Hua A J (2013)
      Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis. Here, ...