Browsing FAS Scholarly Articles by Keyword "zygotic genome activation"

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    • Reprogramming within Hours Following Nuclear Transfer into Mouse but not Human Zygotes 

      Egli, Dieter; Chen, Alice E.; Saphier Belfer, Genevieve C; Ichida, Justin; Fitzgerald, Claire; Go, Kathryn J.; Acevedo, Nicole; Patel, Jay; Baetscher, Manfred; Kearns, William G.; Goland, Robin; Leibel, Rudolph L.; Melton, Douglas A.; Eggan, Kevin Carl (Nature Publishing Group, 2011)
      Fertilized mouse zygotes can reprogram somatic cells to a pluripotent state. Human zygotes might therefore be useful for producing patient-derived pluripotent stem cells. However, logistical, legal and social considerations ...