Browsing FAS Scholarly Articles by Keyword "Cellular Neuroscience"

Now showing items 1-7 of 7

    • 3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing 

      Lakadamyali, Melike; Babcock, Hazen P.; Bates, Mark; Zhuang, Xiaowei; Lichtman, Jeff (Public Library of Science, 2012)
      The connectivity among neurons holds the key to understanding brain function. Mapping neural connectivity in brain circuits requires imaging techniques with high spatial resolution to facilitate neuron tracing and high ...

    • 4-Phenylbutyrate Attenuates the ER Stress Response and Cyclic AMP Accumulation in DYT1 Dystonia Cell Models 

      Cho, Jin A.; Zhang, Xuan; Miller, Gregory M.; Lencer, Wayne I.; Nery, Flavia C. (Public Library of Science, 2014)
      Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia ...

    • Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions 

      Samuel, Melanie Ann; Valdez, Gregorio; Tapia, Juan; Lichtman, Jeff; Sanes, Joshua R. (Public Library of Science, 2012)
      As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ...

    • Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells 

      Naylor, Richard W.; McGhee, Charles N. J.; Cowan, Chad A.; Davidson, Alan J.; Holm, Teresa M.; Sherwin, Trevor (Public Library of Science, 2016)
      Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based ...

    • Normalized Neural Representations of Complex Odors 

      Zwicker, David (Public Library of Science, 2016)
      The olfactory system removes correlations in natural odors using a network of inhibitory neurons in the olfactory bulb. It has been proposed that this network integrates the response from all olfactory receptors and inhibits ...

    • Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body 

      Piccinotti, Silvia; Whelan, Sean P. J. (Public Library of Science, 2016)
      The single glycoprotein (G) of rabies virus (RABV) dictates all viral entry steps from receptor engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells in culture, we generated a recombinant ...

    • Synchronous Symmetry Breaking in Neurons with Different Neurite Counts 

      Wissner-Gross, Zachary Daniel; Scott, Mark A.; Steinmeyer, Joseph D.; Yanik, Mehmet Fatih (Public Library of Science, 2013)
      As neurons develop, several immature processes (i.e., neurites) grow out of the cell body. Over time, each neuron breaks symmetry when only one of its neurites grows much longer than the rest, becoming an axon. This symmetry ...