Now showing items 1-2 of 2

    • Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance 

      Ogbunugafor, C. Brandon; Wylie, C. Scott; Diakite, Ibrahim; Weinreich, Daniel M.; Hartl, Daniel L. (Public Library of Science, 2016)
      The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to ...
    • The Time Scale of Evolutionary Innovation 

      Chatterjee, Krishnendu; Pavlogiannis, Andreas; Adlam, Ben; Nowak, Martin A. (Public Library of Science, 2014)
      A fundamental question in biology is the following: what is the time scale that is needed for evolutionary innovations? There are many results that characterize single steps in terms of the fixation time of new mutants ...