Browsing FAS Scholarly Articles by Keyword "Evolutionary Modeling"

Now showing items 1-7 of 7

    • Can You Sequence Ecology? Metagenomics of Adaptive Diversification 

      Marx, Christopher J (Public Library of Science, 2013)
      Few areas of science have benefited more from the expansion in sequencing capability than the study of microbial communities. Can sequence data, besides providing hypotheses of the functions the members possess, detect the ...

    • The Evolution of Cell-to-Cell Communication in a Sporulating Bacterium 

      van Gestel, Jordi; Nowak, Martin A.; Tarnita, Corina (Public Library of Science, 2012)
      Traditionally microorganisms were considered to be autonomous organisms that could be studied in isolation. However, over the last decades cell-to-cell communication has been found to be ubiquitous. By secreting molecular ...

    • Exploring the miRNA Regulatory Network Using Evolutionary Correlations 

      Obermayer, Benedikt; Levine, Erel (Public Library of Science, 2014)
      Post-transcriptional regulation by miRNAs is a widespread and highly conserved phenomenon in metazoans, with several hundreds to thousands of conserved binding sites for each miRNA, and up to two thirds of all genes under ...

    • Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability 

      Dasmeh, Pouria; Serohijos, Adrian; Kepp, Kasper P.; Shakhnovich, Eugene Isaacovitch (Public Library of Science, 2013)
      Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen ...

    • Selection for Replicases in Protocells 

      Bianconi, Ginestra; Zhao, Kun; Chen, Irene; Nowak, Martin A. (Public Library of Science, 2013)
      We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the ...

    • Sine Systemate Chaos? A Versatile Tool for Earthworm Taxonomy: Non-Destructive Imaging of Freshly Fixed and Museum Specimens Using Micro-Computed Tomography 

      Fernández, Rosa; Kvist, Sebastian; Lenihan, Jennifer; Giribet, Gonzalo; Ziegler, Alexander (Public Library of Science, 2014)
      In spite of the high relevance of lumbricid earthworms (‘Oligochaeta’: Lumbricidae) for soil structure and functioning, the taxonomy of this group of terrestrial invertebrates remains in a quasi-chaotic state. Earthworm ...

    • A Universal Trend among Proteomes Indicates an Oily Last Common Ancestor 

      Mannige, Ranjan V.; Brooks, Charles L.; Shakhnovich, Eugene Isaacovitch (Public Library of Science, 2012)
      Despite progresses in ancestral protein sequence reconstruction, much needs to be unraveled about the nature of the putative last common ancestral proteome that served as the prototype of all extant lifeforms. Here, we ...