Browsing FAS Scholarly Articles by Keyword "cancer genetics"

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    • Comparative Lesion Sequencing Provides Insights into Tumor Evolution 

      Jones, Siân; Chen, Wei-dong; Parmigiani, Giovanni; Diehl, Frank; Beerenwinkel, Niko; Antal, Tibor; Traulsen, Arne; Nowak, Martin A.; Siegel, Christopher; Velculescu, Victor E.; Kinzler, Kenneth W.; Vogelstein, Bert; Willis, Joseph; Markowitz, Sanford D. (Proceedings of the National Academy of Sciences, 2008)
      We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses ...

    • Oscillations and Variability in the P53 System 

      Geva-Zatorsky, Naama; Rosenfeld, Nitzan; Itzkovitz, Shalev; Sigal, Alex; Dekel, Erez; Yarnitzky, Talia; Liron, Yuvalal; Polak, Paz; Alon, Uri; Milo, Ron; Lahav, Galit (Nature Publishing Group, 2006)
      Understanding the dynamics and variability of protein circuitry requires accurate measurements in living cells as well as theoretical models. To address this, we employed one of the best-studied protein circuits in human ...