Browsing FAS Scholarly Articles by Keyword "drug discovery"
Now showing items 1-3 of 3
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Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
(Public Library of Science, 2008)Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical ... -
Empirical Bayes Analysis of Quantitative Proteomics Experiments
(Public Library of Science, 2009)Background: Advances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe ... -
Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate
(Public Library of Science, 2010)The mechanism of membrane fusion by “class II” viral fusion proteins follows a pathway that involves large-scale domain rearrangements of the envelope glycoprotein (E) and a transition from dimers to trimers. The rearrangement ...