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Robust Circadian Oscillations in Growing Cyanobacteria Require Transcriptional Feedback
(American Association for the Advancement of Science, 2013)
The remarkably stable circadian oscillations of single cyanobacteria enable a population of growing cells to maintain synchrony for weeks. The cyanobacterial pacemaker is a posttranslational regulation (PTR) circuit that ...
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
(Cold Spring Harbor Laboratory Press, 2010)
In embryonic stem (ES) cells, a well-characterized transcriptional network promotes pluripotency and represses gene expression required for differentiation. In comparison, the transcriptional networks that promote ...
Atomic Layer Deposition to Fine-Tune the Surface Properties and Diameters of Fabricated Nanopores
(American Chemical Society, 2004)
Atomic layer deposition of alumina enhanced the molecule sensing characteristics of fabricated nanopores by fine-tuning their surface properties, reducing 1/f noise, neutralizing surface charge to favor capture of DNA and ...
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
(Elsevier, 2012)
The Hedgehog signaling pathway is linked to a variety of diseases, notably a range of cancers. The first generation of drug screens identified Smoothened (Smo), a membrane protein essential for signaling, as an attractive ...
Viral Membrane Fusion
(Nature Publishing Group, 2008)
Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral membrane with a membrane of the target cell. Viral ‘fusion proteins’ facilitate this process. They vary greatly in structure, but all ...
Imaging Poliovirus Entry in Live Cells
(Public Library of Science, 2007)
Viruses initiate infection by transferring their genetic material across a cellular membrane and into the appropriate compartment of the cell. The mechanisms by which animal viruses, especially nonenveloped viruses, deliver ...
A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds
(Public Library of Science, 2007)
In this work we develop a microscopic physical model of early evolution where phenotype—organism life expectancy—is directly related to genotype—the stability of its proteins in their native conformations—which can be ...
Interactions of Lipids with Aquaporin-0 and Other Membrane Proteins
(Springer Verlag, 1995)
The structure of aquaporin-0 (AQP0) has recently been determined by electron crystallography of two-dimensional (2D) crystals and by x-ray crystallography of three-dimensional (3D) crystals. The electron crystallographic ...
The Metal Corrdination of sCD39 During ATP Hydrolysis
(BioMed Central, 2001)
Background
The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. In spite of considerable work, it is not clear whether divalent cations ...
GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity
(Public Library of Science, 2012)
Background: Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition ...