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Now showing items 11-20 of 27
Phenotypic Heterogeneity and the Evolution of Bacterial Life Cycles
(Public Library of Science, 2016)
Most bacteria live in colonies, where they often express different cell types. The ecological significance of these cell types and their evolutionary origin are often unknown. Here, we study the evolution of cell differentiation ...
Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case
(Public Library of Science, 2016)
Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic ...
Functional Connectivity in the First Year of Life in Infants at Risk for Autism Spectrum Disorder: An EEG Study
(Public Library of Science, 2014)
In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants ...
The Neural Bases of Directed and Spontaneous Mental State Attributions to Group Agents
(Public Library of Science, 2014)
In daily life, perceivers often need to predict and interpret the behavior of group agents, such as corporations and governments. Although research has investigated how perceivers reason about individual members of particular ...
Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression
(Public Library of Science, 2014)
Background: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the ...
Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT
(Public Library of Science, 2017)
Radiomics aims to quantitatively capture the complex tumor phenotype contained in medical images to associate them with clinical outcomes. This study investigates the impact of different types of computed tomography (CT) ...
Gender Differences in Sustained Attentional Control Relate to Gender Inequality across Countries
(Public Library of Science, 2016)
Sustained attentional control is critical for everyday tasks and success in school and employment. Understanding gender differences in sustained attentional control, and their potential sources, is an important goal of ...
Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells
(Public Library of Science, 2016)
Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based ...
Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling
(Public Library of Science, 2016)
The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell’s environment. This suggests that the external environment may be harnessed to interrogate the cell’s ...
Executive Function, Visual Attention and the Cocktail Party Problem in Musicians and Non-Musicians
(Public Library of Science, 2016)
The goal of this study was to investigate how cognitive factors influence performance in a multi-talker, “cocktail-party” like environment in musicians and non-musicians. This was achieved by relating performance in a ...