Search
Now showing items 31-40 of 61
Human Visual Search Does Not Maximize the Post-Saccadic Probability of Identifying Targets
(Public Library of Science, 2012)
Researchers have conjectured that eye movements during visual search are selected to minimize the number of saccades. The optimal Bayesian eye movement strategy minimizing saccades does not simply direct the eye to whichever ...
A Spontaneous Mutation in Contactin 1 in the Mouse
(Public Library of Science, 2011)
Mutations in the gene encoding the immunoglobulin-superfamily member cell adhesion molecule contactin1 (CNTN1) cause lethal congenital myopathy in human patients and neurodevelopmental phenotypes in knockout mice. Whether ...
3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing
(Public Library of Science, 2012)
The connectivity among neurons holds the key to understanding brain function. Mapping neural connectivity in brain circuits requires imaging techniques with high spatial resolution to facilitate neuron tracing and high ...
Angiotensin II Induced Cardiac Dysfunction on a Chip
(Public Library of Science, 2016)
In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...
4-Phenylbutyrate Attenuates the ER Stress Response and Cyclic AMP Accumulation in DYT1 Dystonia Cell Models
(Public Library of Science, 2014)
Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia ...
Investigating the Neural Correlates of Voice versus Speech-Sound Directed Information in Pre-School Children
(Public Library of Science, 2014)
Studies in sleeping newborns and infants propose that the superior temporal sulcus is involved in speech processing soon after birth. Speech processing also implicitly requires the analysis of the human voice, which conveys ...
Intrinsic Neuronal Properties Switch the Mode of Information Transmission in Networks
(Public Library of Science, 2014)
Diverse ion channels and their dynamics endow single neurons with complex biophysical properties. These properties determine the heterogeneity of cell types that make up the brain, as constituents of neural circuits tuned ...
Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body
(Public Library of Science, 2016)
The single glycoprotein (G) of rabies virus (RABV) dictates all viral entry steps from receptor engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells in culture, we generated a recombinant ...
Anticipation of Monetary Reward Can Attenuate the Vigilance Decrement
(Public Library of Science, 2016)
Motivation and reward can have differential effects on separate aspects of sustained attention. We previously demonstrated that continuous reward/punishment throughout a sustained attention task improves overall performance, ...
Patterns of Brain Activation when Mothers View Their Own Child and Dog: An fMRI Study
(Public Library of Science, 2014)
Neural substrates underlying the human-pet relationship are largely unknown. We examined fMRI brain activation patterns as mothers viewed images of their own child and dog and an unfamiliar child and dog. There was a common ...