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dc.contributor.authorKundaje, Anshulen_US
dc.contributor.authorMeuleman, Wouteren_US
dc.contributor.authorErnst, Jasonen_US
dc.contributor.authorBilenky, Mishaen_US
dc.contributor.authorYen, Angelaen_US
dc.contributor.authorKheradpour, Pouyaen_US
dc.contributor.authorZhang, Zhizhuoen_US
dc.contributor.authorHeravi-Moussavi, Alirezaen_US
dc.contributor.authorLiu, Yapingen_US
dc.contributor.authorAmin, Virenen_US
dc.contributor.authorZiller, Michael Jen_US
dc.contributor.authorWhitaker, John Wen_US
dc.contributor.authorSchultz, Matthew Den_US
dc.contributor.authorSandstrom, Richard Sen_US
dc.contributor.authorEaton, Matthew Len_US
dc.contributor.authorWu, Yi-Chiehen_US
dc.contributor.authorWang, Jianrongen_US
dc.contributor.authorWard, Lucas Den_US
dc.contributor.authorSarkar, Abhisheken_US
dc.contributor.authorQuon, Geralden_US
dc.contributor.authorPfenning, Andreasen_US
dc.contributor.authorWang, Xinchenen_US
dc.contributor.authorClaussnitzer, Melinaen_US
dc.contributor.authorCoarfa, Cristianen_US
dc.contributor.authorHarris, R Alanen_US
dc.contributor.authorShoresh, Noamen_US
dc.contributor.authorEpstein, Charles Ben_US
dc.contributor.authorGjoneska, Elizabetaen_US
dc.contributor.authorLeung, Dannyen_US
dc.contributor.authorXie, Weien_US
dc.contributor.authorHawkins, R Daviden_US
dc.contributor.authorLister, Ryanen_US
dc.contributor.authorHong, Chiboen_US
dc.contributor.authorGascard, Philippeen_US
dc.contributor.authorMungall, Andrew Jen_US
dc.contributor.authorMoore, Richarden_US
dc.contributor.authorChuah, Ericen_US
dc.contributor.authorTam, Angelaen_US
dc.contributor.authorCanfield, Theresa Ken_US
dc.contributor.authorHansen, R Scotten_US
dc.contributor.authorKaul, Rajinderen_US
dc.contributor.authorSabo, Peter Jen_US
dc.contributor.authorBansal, Mukul Sen_US
dc.contributor.authorCarles, Annaicken_US
dc.contributor.authorDixon, Jesse Ren_US
dc.contributor.authorFarh, Kai-Howen_US
dc.contributor.authorFeizi, Soheilen_US
dc.contributor.authorKarlic, Rosaen_US
dc.contributor.authorKim, Ah-Ramen_US
dc.contributor.authorKulkarni, Ashwinikumaren_US
dc.contributor.authorLi, Daofengen_US
dc.contributor.authorLowdon, Rebeccaen_US
dc.contributor.authorMercer, Tim Ren_US
dc.contributor.authorNeph, Shane Jen_US
dc.contributor.authorOnuchic, Vitoren_US
dc.contributor.authorPolak, Pazen_US
dc.contributor.authorRajagopal, Nishaen_US
dc.contributor.authorRay, Pradiptaen_US
dc.contributor.authorSallari, Richard Cen_US
dc.contributor.authorSiebenthall, Kyle Ten_US
dc.contributor.authorSinnott-Armstrong, Nicholasen_US
dc.contributor.authorStevens, Michaelen_US
dc.contributor.authorThurman, Robert Een_US
dc.contributor.authorWu, Jieen_US
dc.contributor.authorZhang, Boen_US
dc.contributor.authorZhou, Xinen_US
dc.contributor.authorBeaudet, Arthur Een_US
dc.contributor.authorBoyer, Laurie Aen_US
dc.contributor.authorDe Jager, Philipen_US
dc.contributor.authorFarnham, Peggy Jen_US
dc.contributor.authorFisher, Susan Jen_US
dc.contributor.authorHaussler, Daviden_US
dc.contributor.authorJones, Stevenen_US
dc.contributor.authorLi, Weien_US
dc.contributor.authorMarra, Marcoen_US
dc.contributor.authorMcManus, Michael Ten_US
dc.contributor.authorSunyaev, Shamilen_US
dc.contributor.authorThomson, James Aen_US
dc.contributor.authorTlsty, Thea Den_US
dc.contributor.authorTsai, Li-Hueien_US
dc.contributor.authorWang, Weien_US
dc.contributor.authorWaterland, Robert Aen_US
dc.contributor.authorZhang, Michaelen_US
dc.contributor.authorChadwick, Lisa Hen_US
dc.contributor.authorBernstein, Bradley Een_US
dc.contributor.authorCostello, Joseph Fen_US
dc.contributor.authorEcker, Joseph Ren_US
dc.contributor.authorHirst, Martinen_US
dc.contributor.authorMeissner, Alexanderen_US
dc.contributor.authorMilosavljevic, Aleksandaren_US
dc.contributor.authorRen, Bingen_US
dc.contributor.authorStamatoyannopoulos, John Aen_US
dc.contributor.authorWang, Tingen_US
dc.contributor.authorKellis, Manolisen_US
dc.date.accessioned2015-09-01T13:26:26Z
dc.date.issued2015en_US
dc.identifier.citationKundaje, A., W. Meuleman, J. Ernst, M. Bilenky, A. Yen, P. Kheradpour, Z. Zhang, et al. 2015. “Integrative analysis of 111 reference human epigenomes.” Nature 518 (7539): 317-330. doi:10.1038/nature14248. http://dx.doi.org/10.1038/nature14248.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21458829
dc.description.abstractThe reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but a similar reference has lacked for epigenomic studies. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection to-date of human epigenomes for primary cells and tissues. Here, we describe the integrative analysis of 111 reference human epigenomes generated as part of the program, profiled for histone modification patterns, DNA accessibility, DNA methylation, and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically-relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation, and human disease.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature14248en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010/pdf/en
dash.licenseLAAen_US
dc.titleIntegrative analysis of 111 reference human epigenomesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorZiller, Michael Jen_US
dc.date.available2015-09-01T13:26:26Z
dc.identifier.doi10.1038/nature14248*
dash.authorsorderedfalse
dash.contributor.affiliatedZiller, Michael
dash.contributor.affiliatedDe Jager, Philip
dash.contributor.affiliatedSunyaev, Shamil
dash.contributor.affiliatedBernstein, Bradley


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