Show simple item record

dc.contributor.authorHuynh, Alexandriaen_US
dc.contributor.authorDuPage, Michelen_US
dc.contributor.authorPriyadharshini, Bhavanaen_US
dc.contributor.authorSage, Peter T.en_US
dc.contributor.authorQuiros, Jasonen_US
dc.contributor.authorBorges, Christopher M.en_US
dc.contributor.authorTownamchai, Natavudhen_US
dc.contributor.authorGerriets, Valerie A.en_US
dc.contributor.authorRathmell, Jeffrey C.en_US
dc.contributor.authorSharpe, Arlene H.en_US
dc.contributor.authorBluestone, Jeffrey A.en_US
dc.contributor.authorTurka, Laurence A.en_US
dc.date.accessioned2015-09-01T13:26:27Z
dc.date.issued2014en_US
dc.identifier.citationHuynh, A., M. DuPage, B. Priyadharshini, P. T. Sage, J. Quiros, C. M. Borges, N. Townamchai, et al. 2014. “The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability.” Nature immunology 16 (2): 188-196. doi:10.1038/ni.3077. http://dx.doi.org/10.1038/ni.3077.en
dc.identifier.issn1529-2908en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21458840
dc.description.abstractFoxp3+ regulatory T cells (Tregs) are required for immune homeostasis. One notable distinction between conventional T cells (Tconv) and Tregs is differential phosphatidylinositol 3-kinase (PI3K) activity: only Tconv downregulate PTEN, the primary negative regulator of PI3K, upon activation. Here, we show that control of PI3K in Tregs is essential for lineage homeostasis and stability. Mice lacking Pten in Tregs developed an autoimmune-lymphoproliferative disease characterized by excessive TH1 responses and B cell activation. Diminished control of PI3K activity in Tregs led to reduced CD25 expression, accumulation of Foxp3+CD25− cells and ultimately, loss of Foxp3 expression in these cells. Collectively, these data demonstrate that control of PI3K signaling by PTEN in Tregs is critical to maintain their homeostasis, function and stability.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ni.3077en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515/pdf/en
dash.licenseLAAen_US
dc.titleThe phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stabilityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature immunologyen
dash.depositing.authorPriyadharshini, Bhavanaen_US
dc.date.available2015-09-01T13:26:27Z
dc.identifier.doi10.1038/ni.3077*
dash.authorsorderedfalse
dash.contributor.affiliatedPriyadharshini, Bhavana
dash.contributor.affiliatedBorges, Christopher M.
dash.contributor.affiliatedTurka, Laurence
dash.contributor.affiliatedSage, Peter
dash.contributor.affiliatedSharpe, Arlene


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record