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dc.contributor.authorLongo, Valter Den_US
dc.contributor.authorAntebi, Adamen_US
dc.contributor.authorBartke, Andrzejen_US
dc.contributor.authorBarzilai, Niren_US
dc.contributor.authorBrown-Borg, Holly Men_US
dc.contributor.authorCaruso, Calogeroen_US
dc.contributor.authorCuriel, Tyler Jen_US
dc.contributor.authorde Cabo, Rafaelen_US
dc.contributor.authorFranceschi, Claudioen_US
dc.contributor.authorGems, Daviden_US
dc.contributor.authorIngram, Donald Ken_US
dc.contributor.authorJohnson, Thomas Een_US
dc.contributor.authorKennedy, Brian Ken_US
dc.contributor.authorKenyon, Cynthiaen_US
dc.contributor.authorKlein, Samuelen_US
dc.contributor.authorKopchick, John Jen_US
dc.contributor.authorLepperdinger, Guenteren_US
dc.contributor.authorMadeo, Franken_US
dc.contributor.authorMirisola, Mario Gen_US
dc.contributor.authorMitchell, James Ren_US
dc.contributor.authorPassarino, Giuseppeen_US
dc.contributor.authorRudolph, Karl Len_US
dc.contributor.authorSedivy, John Men_US
dc.contributor.authorShadel, Gerald Sen_US
dc.contributor.authorSinclair, David Aen_US
dc.contributor.authorSpindler, Stephen Ren_US
dc.contributor.authorSuh, Yousinen_US
dc.contributor.authorVijg, Janen_US
dc.contributor.authorVinciguerra, Manlioen_US
dc.contributor.authorFontana, Luigien_US
dc.date.accessioned2015-09-01T13:26:52Z
dc.date.issued2015en_US
dc.identifier.citationLongo, V. D., A. Antebi, A. Bartke, N. Barzilai, H. M. Brown-Borg, C. Caruso, T. J. Curiel, et al. 2015. “Interventions to Slow Aging in Humans: Are We Ready?” Aging Cell 14 (4): 497-510. doi:10.1111/acel.12338. http://dx.doi.org/10.1111/acel.12338.en
dc.identifier.issn1474-9718en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21459232
dc.description.abstractThe workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR–S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.en
dc.language.isoen_USen
dc.publisherJohn Wiley & Sons, Ltden
dc.relation.isversionofdoi:10.1111/acel.12338en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531065/pdf/en
dash.licenseLAAen_US
dc.subjectagingen
dc.subjectanti-agingen
dc.subjectcentenariansen
dc.subjectlongevity regulationen
dc.subjectdietary restrictionen
dc.subjectlifespan studiesen
dc.subjectlongevity geneen
dc.titleInterventions to Slow Aging in Humans: Are We Ready?en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAging Cellen
dash.depositing.authorMitchell, James Ren_US
dc.date.available2015-09-01T13:26:52Z
dc.identifier.doi10.1111/acel.12338*
dash.authorsorderedfalse
dash.contributor.affiliatedMitchell, James
dash.contributor.affiliatedSinclair, David


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