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dc.contributor.authorShungin, Dmitryen_US
dc.contributor.authorWinkler, Thomas Wen_US
dc.contributor.authorCroteau-Chonka, Damien Cen_US
dc.contributor.authorFerreira, Teresaen_US
dc.contributor.authorLocke, Adam Een_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorStrawbridge, Rona Jen_US
dc.contributor.authorPers, Tune Hen_US
dc.contributor.authorFischer, Kristaen_US
dc.contributor.authorJustice, Anne Een_US
dc.contributor.authorWorkalemahu, Tsegaselassieen_US
dc.contributor.authorWu, Joseph M.W.en_US
dc.contributor.authorBuchkovich, Martin Len_US
dc.contributor.authorHeard-Costa, Nancy Len_US
dc.contributor.authorRoman, Tamara Sen_US
dc.contributor.authorDrong, Alexander Wen_US
dc.contributor.authorSong, Cien_US
dc.contributor.authorGustafsson, Stefanen_US
dc.contributor.authorDay, Felix Ren_US
dc.contributor.authorEsko, Tonuen_US
dc.contributor.authorFall, Toveen_US
dc.contributor.authorKutalik, Zoltánen_US
dc.contributor.authorLuan, Jian’anen_US
dc.contributor.authorRandall, Joshua Cen_US
dc.contributor.authorScherag, Andréen_US
dc.contributor.authorVedantam, Sailajaen_US
dc.contributor.authorWood, Andrew Ren_US
dc.contributor.authorChen, Jinen_US
dc.contributor.authorFehrmann, Rudolfen_US
dc.contributor.authorKarjalainen, Juhaen_US
dc.contributor.authorKahali, Bratatien_US
dc.contributor.authorLiu, Ching-Tien_US
dc.contributor.authorSchmidt, Ellen Men_US
dc.contributor.authorAbsher, Devinen_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorAnderson, Deniseen_US
dc.contributor.authorBeekman, Marianen_US
dc.contributor.authorBragg-Gresham, Jennifer Len_US
dc.contributor.authorBuyske, Stevenen_US
dc.contributor.authorDemirkan, Ayseen_US
dc.contributor.authorEhret, Georg Ben_US
dc.contributor.authorFeitosa, Mary Fen_US
dc.contributor.authorGoel, Anujen_US
dc.contributor.authorJackson, Anne Uen_US
dc.contributor.authorJohnson, Tobyen_US
dc.contributor.authorKleber, Marcus Een_US
dc.contributor.authorKristiansson, Katien_US
dc.contributor.authorMangino, Massimoen_US
dc.contributor.authorLeach, Irene Mateoen_US
dc.contributor.authorMedina-Gomez, Carolinaen_US
dc.contributor.authorPalmer, Cameron Den_US
dc.contributor.authorPasko, Dorotaen_US
dc.contributor.authorPechlivanis, Sonalien_US
dc.contributor.authorPeters, Marjolein Jen_US
dc.contributor.authorProkopenko, Ingaen_US
dc.contributor.authorStančáková, Alenaen_US
dc.contributor.authorSung, Yun Juen_US
dc.contributor.authorTanaka, Toshikoen_US
dc.contributor.authorTeumer, Alexanderen_US
dc.contributor.authorVan Vliet-Ostaptchouk, Jana Ven_US
dc.contributor.authorYengo, Loïcen_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorAlbrecht, Evaen_US
dc.contributor.authorÄrnlöv, Johanen_US
dc.contributor.authorArscott, Gillian Men_US
dc.contributor.authorBandinelli, Stefaniaen_US
dc.contributor.authorBarrett, Amyen_US
dc.contributor.authorBellis, Claireen_US
dc.contributor.authorBennett, Amanda Jen_US
dc.contributor.authorBerne, Christianen_US
dc.contributor.authorBlüher, Matthiasen_US
dc.contributor.authorBöhringer, Stefanen_US
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dc.contributor.authorBöttcher, Yvonneen_US
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dc.contributor.authorCarba, Delia Ben_US
dc.contributor.authorCaspersen, Ida Hen_US
dc.contributor.authorClarke, Roberten_US
dc.contributor.authorDaw, E Warwicken_US
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dc.contributor.authorDeelman, Ewaen_US
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dc.contributor.authorHerzig, Karl-Heinzen_US
dc.contributor.authorHelmer, Quintaen_US
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dc.contributor.authorHunt, Steven Cen_US
dc.contributor.authorIsaacs, Aaronen_US
dc.contributor.authorIttermann, Tillen_US
dc.contributor.authorJames, Alan Len_US
dc.contributor.authorJohansson, Ingegerden_US
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dc.contributor.authorKinnunen, Leenaen_US
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dc.contributor.authorKratzer, Wolfgangen_US
dc.contributor.authorLamina, Claudiaen_US
dc.contributor.authorLeander, Karinen_US
dc.contributor.authorLee, Nanette Ren_US
dc.contributor.authorLichtner, Peteren_US
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dc.contributor.authorLobbens, Stéphaneen_US
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dc.contributor.authorNagaraja, Ramaiahen_US
dc.contributor.authorNalls, Michael Aen_US
dc.contributor.authorNarisu, Narisuen_US
dc.contributor.authorGlorioso, Nicolaen_US
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dc.contributor.authorRenstrom, Fridaen_US
dc.contributor.authorRied, Janina Sen_US
dc.contributor.authorRobertson, Neil Ren_US
dc.contributor.authorRose, Lynda Men_US
dc.contributor.authorSanna, Serenaen_US
dc.contributor.authorScharnagl, Huberten_US
dc.contributor.authorScholtens, Salomeen_US
dc.contributor.authorSennblad, Bengten_US
dc.contributor.authorSeufferlein, Thomasen_US
dc.contributor.authorSitlani, Colleen Men_US
dc.contributor.authorSmith, Albert Vernonen_US
dc.contributor.authorStirrups, Kathleenen_US
dc.contributor.authorStringham, Heather Men_US
dc.contributor.authorSundström, Johanen_US
dc.contributor.authorSwertz, Morris Aen_US
dc.contributor.authorSwift, Amy Jen_US
dc.contributor.authorSyvänen, Ann-Christineen_US
dc.contributor.authorTayo, Bamidele Oen_US
dc.contributor.authorThorand, Barbaraen_US
dc.contributor.authorThorleifsson, Gudmaren_US
dc.contributor.authorTomaschitz, Andreasen_US
dc.contributor.authorTroffa, Chiaraen_US
dc.contributor.authorvan Oort, Floor VAen_US
dc.contributor.authorVerweij, Nieken_US
dc.contributor.authorVonk, Judith Men_US
dc.contributor.authorWaite, Lindsay Len_US
dc.contributor.authorWennauer, Romanen_US
dc.contributor.authorWilsgaard, Tomen_US
dc.contributor.authorWojczynski, Mary Ken_US
dc.contributor.authorWong, Andrewen_US
dc.contributor.authorZhang, Qunyuanen_US
dc.contributor.authorZhao, Jing Huaen_US
dc.contributor.authorBrennan, Eoin P.en_US
dc.contributor.authorChoi, Murimen_US
dc.contributor.authorEriksson, Peren_US
dc.contributor.authorFolkersen, Lasseen_US
dc.contributor.authorFranco-Cereceda, Andersen_US
dc.contributor.authorGharavi, Ali Gen_US
dc.contributor.authorHedman, Åsa Ken_US
dc.contributor.authorHivert, Marie-Franceen_US
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dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMin, Josine Len_US
dc.contributor.authorMoffatt, Miriam Fen_US
dc.contributor.authorMontgomery, Grant Wen_US
dc.contributor.authorMurabito, Joanne Men_US
dc.contributor.authorNicholson, Georgeen_US
dc.contributor.authorNyholt, Dale Ren_US
dc.contributor.authorOlsson, Christianen_US
dc.contributor.authorPerry, John RBen_US
dc.contributor.authorReinmaa, Evaen_US
dc.contributor.authorSalem, Rany Men_US
dc.contributor.authorSandholm, Niinaen_US
dc.contributor.authorSchadt, Eric Een_US
dc.contributor.authorScott, Robert Aen_US
dc.contributor.authorStolk, Lisetteen_US
dc.contributor.authorVallejo, Edgar E.en_US
dc.contributor.authorWestra, Harm-Janen_US
dc.contributor.authorZondervan, Krina Ten_US
dc.contributor.authorAmouyel, Philippeen_US
dc.contributor.authorArveiler, Dominiqueen_US
dc.contributor.authorBakker, Stephan JLen_US
dc.contributor.authorBeilby, Johnen_US
dc.contributor.authorBergman, Richard Nen_US
dc.contributor.authorBlangero, Johnen_US
dc.contributor.authorBrown, Morris Jen_US
dc.contributor.authorBurnier, Michelen_US
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dc.contributor.authorChines, Peter Sen_US
dc.contributor.authorClaudi-Boehm, Simoneen_US
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dc.contributor.authorCrawford, Dana Cen_US
dc.contributor.authorDanesh, Johnen_US
dc.contributor.authorde Faire, Ulfen_US
dc.contributor.authorde Geus, Eco JCen_US
dc.contributor.authorDörr, Marcusen_US
dc.contributor.authorErbel, Raimunden_US
dc.contributor.authorEriksson, Johan Gen_US
dc.contributor.authorFarrall, Martinen_US
dc.contributor.authorFerrannini, Eleen_US
dc.contributor.authorFerrières, Jeanen_US
dc.contributor.authorForouhi, Nita Gen_US
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dc.contributor.authorFranco, Oscar Hen_US
dc.contributor.authorGansevoort, Ron Ten_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHaiman, Christopher Aen_US
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dc.contributor.authorHeliövaara, Markkuen_US
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dc.contributor.authorHofman, Alberten_US
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dc.contributor.authorHumphries, Steve Een_US
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dc.contributor.authorNjølstad, Ingeren_US
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dc.contributor.authorPalmer, Colin NAen_US
dc.contributor.authorPedersen, Nancy Len_US
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dc.contributor.authorPower, Chrisen_US
dc.contributor.authorQuertermous, Thomasen_US
dc.contributor.authorRauramaa, Raineren_US
dc.contributor.authorRivadeneira, Fernandoen_US
dc.contributor.authorSaaristo, Timo Een_US
dc.contributor.authorSaleheen, Danishen_US
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dc.contributor.authorSlagboom, P Elineen_US
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dc.contributor.authorGroop, Leif Cen_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorKaplan, Robert Cen_US
dc.contributor.authorO’Connell, Jeffrey Ren_US
dc.contributor.authorQi, Luen_US
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dc.contributor.authorVisscher, Peter Men_US
dc.contributor.authorYang, Jianen_US
dc.contributor.authorHirschhorn, Joel Nen_US
dc.contributor.authorZillikens, M Carolaen_US
dc.contributor.authorMcCarthy, Mark Ien_US
dc.contributor.authorSpeliotes, Elizabeth Ken_US
dc.contributor.authorNorth, Kari Een_US
dc.contributor.authorFox, Caroline Sen_US
dc.contributor.authorBarroso, Inêsen_US
dc.contributor.authorFranks, Paul Wen_US
dc.contributor.authorIngelsson, Eriken_US
dc.contributor.authorHeid, Iris Men_US
dc.contributor.authorLoos, Ruth JFen_US
dc.contributor.authorCupples, L Adrienneen_US
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dc.contributor.authorLindgren, Cecilia Men_US
dc.contributor.authorMohlke, Karen Len_US
dc.date.accessioned2015-09-01T13:26:53Z
dc.date.issued2014en_US
dc.identifier.citationShungin, D., T. W. Winkler, D. C. Croteau-Chonka, T. Ferreira, A. E. Locke, R. Mägi, R. J. Strawbridge, et al. 2014. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518 (7538): 187-196. doi:10.1038/nature14132. http://dx.doi.org/10.1038/nature14132.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21459269
dc.description.abstractBody fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10−8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature14132en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338562/pdf/en
dash.licenseLAAen_US
dc.titleNew genetic loci link adipose and insulin biology to body fat distributionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorCroteau-Chonka, Damien Cen_US
dc.date.available2015-09-01T13:26:53Z
dc.identifier.doi10.1038/nature14132*
dash.authorsorderedfalse
dash.contributor.affiliatedCroteau-Chonka, Damien
dash.contributor.affiliatedEsko, Tõnu
dash.contributor.affiliatedHivert, Marie-France
dash.contributor.affiliatedLiang, Liming
dash.contributor.affiliatedRidker, Paul
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedFranks, Paul
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedHunter, David
dash.contributor.affiliatedHirschhorn, Joel
dc.identifier.orcid0000-0003-1982-6569
dc.identifier.orcid0000-0003-1249-4522


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