Large-scale genomics unveil polygenic architecture of human cortical surface area

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Author
Chen, Chi-Hua
Peng, Qian
Schork, Andrew J.
Lo, Min-Tzu
Fan, Chun-Chieh
Wang, Yunpeng
Desikan, Rahul S.
Bettella, Francesco
Hagler, Donald J.
McCabe, Connor
Chang, Linda
Akshoomoff, Natacha
Newman, Erik
Ernst, Thomas
Van Zijl, Peter
Kuperman, Joshua
Murray, Sarah
Bloss, Cinnamon
Appelbaum, Mark
Gamst, Anthony
Thompson, Wesley
Bartsch, Hauke
Weiner, Michael
Aisen, Paul
Petersen, Ronald
Jack Jr, Clifford R.
Jagust, William
Trojanowki, John Q.
Toga, Arthur W.
Beckett, Laurel
Saykin, Andrew J.
Morris, John
Shaw, Leslie M.
Khachaturian, Zaven
Sorensen, Greg
Carrillo, Maria
Kuller, Lew
Raichle, Marc
Paul, Steven
Davies, Peter
Fillit, Howard
Hefti, Franz
Holtzman, Davie
Mesulman, M. Marcel
Potter, William
Snyder, Peter J.
Schwartz, Adam
Montine, Tom
Thomas, Ronald G.
Donohue, Michael
Walter, Sarah
Gessert, Devon
Sather, Tamie
Jiminez, Gus
Harvey, Danielle
Bernstein, Matthew
Fox, Nick
Thompson, Paul
Schuff, Norbert
DeCarli, Charles
Borowski, Bret
Gunter, Jeff
Senjem, Matt
Vemuri, Prashanthi
Jones, David
Kantarci, Kejal
Ward, Chad
Koeppe, Robert A.
Foster, Norm
Reiman, Eric M.
Chen, Kewei
Mathis, Chet
Landau, Susan
Cairns, Nigel J.
Householder, Erin
Taylor-Reinwald, Lisa
Lee, Virginia M.Y.
Korecka, Magdalena
Figurski, Michal
Crawford, Karen
Neu, Scott
Foroud, Tatiana M.
Potkin, Steven
Shen, Li
Faber, Kelley
Kim, Sungeun
Nho, Kwangsik
Thal, Leon
Frank, Richard
Buckholtz, Neil
Albert, Marilyn
Hsiao, John
Westlye, Lars T.
Kremen, William S.
Jernigan, Terry L.
Hellard, Stephanie Le
Steen, Vidar M.
Espeseth, Thomas
Huentelman, Matt
Håberg, Asta K.
Agartz, Ingrid
Djurovic, Srdjan
Andreassen, Ole A.
Schork, Nicholas
Dale, Anders M.
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Published Version
https://doi.org/10.1038/ncomms8549Metadata
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Chen, C., Q. Peng, A. J. Schork, M. Lo, C. Fan, Y. Wang, R. S. Desikan, et al. 2015. “Large-scale genomics unveil polygenic architecture of human cortical surface area.” Nature Communications 6 (1): 7549. doi:10.1038/ncomms8549. http://dx.doi.org/10.1038/ncomms8549.Abstract
Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h2∼0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518289/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462047
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