Show simple item record

dc.contributor.authorChen, Chi-Huaen_US
dc.contributor.authorPeng, Qianen_US
dc.contributor.authorSchork, Andrew J.en_US
dc.contributor.authorLo, Min-Tzuen_US
dc.contributor.authorFan, Chun-Chiehen_US
dc.contributor.authorWang, Yunpengen_US
dc.contributor.authorDesikan, Rahul S.en_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorHagler, Donald J.en_US
dc.contributor.authorMcCabe, Connoren_US
dc.contributor.authorChang, Lindaen_US
dc.contributor.authorAkshoomoff, Natachaen_US
dc.contributor.authorNewman, Eriken_US
dc.contributor.authorErnst, Thomasen_US
dc.contributor.authorVan Zijl, Peteren_US
dc.contributor.authorKuperman, Joshuaen_US
dc.contributor.authorMurray, Sarahen_US
dc.contributor.authorBloss, Cinnamonen_US
dc.contributor.authorAppelbaum, Marken_US
dc.contributor.authorGamst, Anthonyen_US
dc.contributor.authorThompson, Wesleyen_US
dc.contributor.authorBartsch, Haukeen_US
dc.contributor.authorWeiner, Michaelen_US
dc.contributor.authorAisen, Paulen_US
dc.contributor.authorPetersen, Ronalden_US
dc.contributor.authorJack Jr, Clifford R.en_US
dc.contributor.authorJagust, Williamen_US
dc.contributor.authorTrojanowki, John Q.en_US
dc.contributor.authorToga, Arthur W.en_US
dc.contributor.authorBeckett, Laurelen_US
dc.contributor.authorGreen, Robert C.en_US
dc.contributor.authorSaykin, Andrew J.en_US
dc.contributor.authorMorris, Johnen_US
dc.contributor.authorShaw, Leslie M.en_US
dc.contributor.authorKhachaturian, Zavenen_US
dc.contributor.authorSorensen, Gregen_US
dc.contributor.authorCarrillo, Mariaen_US
dc.contributor.authorKuller, Lewen_US
dc.contributor.authorRaichle, Marcen_US
dc.contributor.authorPaul, Stevenen_US
dc.contributor.authorDavies, Peteren_US
dc.contributor.authorFillit, Howarden_US
dc.contributor.authorHefti, Franzen_US
dc.contributor.authorHoltzman, Davieen_US
dc.contributor.authorMesulman, M. Marcelen_US
dc.contributor.authorPotter, Williamen_US
dc.contributor.authorSnyder, Peter J.en_US
dc.contributor.authorSchwartz, Adamen_US
dc.contributor.authorMontine, Tomen_US
dc.contributor.authorThomas, Ronald G.en_US
dc.contributor.authorDonohue, Michaelen_US
dc.contributor.authorWalter, Sarahen_US
dc.contributor.authorGessert, Devonen_US
dc.contributor.authorSather, Tamieen_US
dc.contributor.authorJiminez, Gusen_US
dc.contributor.authorHarvey, Danielleen_US
dc.contributor.authorBernstein, Matthewen_US
dc.contributor.authorFox, Nicken_US
dc.contributor.authorThompson, Paulen_US
dc.contributor.authorSchuff, Norberten_US
dc.contributor.authorDeCarli, Charlesen_US
dc.contributor.authorBorowski, Breten_US
dc.contributor.authorGunter, Jeffen_US
dc.contributor.authorSenjem, Matten_US
dc.contributor.authorVemuri, Prashanthien_US
dc.contributor.authorJones, Daviden_US
dc.contributor.authorKantarci, Kejalen_US
dc.contributor.authorWard, Chaden_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorFoster, Normen_US
dc.contributor.authorReiman, Eric M.en_US
dc.contributor.authorChen, Keweien_US
dc.contributor.authorMathis, Cheten_US
dc.contributor.authorLandau, Susanen_US
dc.contributor.authorCairns, Nigel J.en_US
dc.contributor.authorHouseholder, Erinen_US
dc.contributor.authorTaylor-Reinwald, Lisaen_US
dc.contributor.authorLee, Virginia M.Y.en_US
dc.contributor.authorKorecka, Magdalenaen_US
dc.contributor.authorFigurski, Michalen_US
dc.contributor.authorCrawford, Karenen_US
dc.contributor.authorNeu, Scotten_US
dc.contributor.authorForoud, Tatiana M.en_US
dc.contributor.authorPotkin, Stevenen_US
dc.contributor.authorShen, Lien_US
dc.contributor.authorFaber, Kelleyen_US
dc.contributor.authorKim, Sungeunen_US
dc.contributor.authorNho, Kwangsiken_US
dc.contributor.authorThal, Leonen_US
dc.contributor.authorFrank, Richarden_US
dc.contributor.authorBuckholtz, Neilen_US
dc.contributor.authorAlbert, Marilynen_US
dc.contributor.authorHsiao, Johnen_US
dc.contributor.authorWestlye, Lars T.en_US
dc.contributor.authorKremen, William S.en_US
dc.contributor.authorJernigan, Terry L.en_US
dc.contributor.authorHellard, Stephanie Leen_US
dc.contributor.authorSteen, Vidar M.en_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorHuentelman, Matten_US
dc.contributor.authorHåberg, Asta K.en_US
dc.contributor.authorAgartz, Ingriden_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAndreassen, Ole A.en_US
dc.contributor.authorSchork, Nicholasen_US
dc.contributor.authorDale, Anders M.en_US
dc.date.accessioned2015-09-01T13:28:02Z
dc.date.issued2015en_US
dc.identifier.citationChen, C., Q. Peng, A. J. Schork, M. Lo, C. Fan, Y. Wang, R. S. Desikan, et al. 2015. “Large-scale genomics unveil polygenic architecture of human cortical surface area.” Nature Communications 6 (1): 7549. doi:10.1038/ncomms8549. http://dx.doi.org/10.1038/ncomms8549.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462047
dc.description.abstractLittle is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h2∼0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.en
dc.language.isoen_USen
dc.publisherNature Pub. Groupen
dc.relation.isversionofdoi:10.1038/ncomms8549en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518289/pdf/en
dash.licenseLAAen_US
dc.titleLarge-scale genomics unveil polygenic architecture of human cortical surface areaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorGreen, Robert C.en_US
dc.date.available2015-09-01T13:28:02Z
dc.identifier.doi10.1038/ncomms8549*
dash.authorsorderedfalse
dash.contributor.affiliatedGreen, Robert


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record