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dc.contributor.authorWalker, Sarah R.en_US
dc.contributor.authorLiu, Suhuen_US
dc.contributor.authorXiang, Michaelen_US
dc.contributor.authorNicolais, Mariaen_US
dc.contributor.authorHatzi, Katerinaen_US
dc.contributor.authorGiannopoulou, Eugeniaen_US
dc.contributor.authorElemento, Olivieren_US
dc.contributor.authorCerchietti, Leandroen_US
dc.contributor.authorMelnick, Arien_US
dc.contributor.authorFrank, David A.en_US
dc.date.accessioned2015-09-01T13:28:09Z
dc.date.issued2014en_US
dc.identifier.citationWalker, Sarah R., Suhu Liu, Michael Xiang, Maria Nicolais, Katerina Hatzi, Eugenia Giannopoulou, Olivier Elemento, Leandro Cerchietti, Ari Melnick, and David A. Frank. 2014. “The transcriptional modulator BCL6 as a molecular target for breast cancer therapy.” Oncogene 34 (9): 1073-1082. doi:10.1038/onc.2014.61. http://dx.doi.org/10.1038/onc.2014.61.en
dc.identifier.issn0950-9232en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462162
dc.description.abstractInappropriate expression or activation of transcription factors can drive patterns of gene expression leading to the malignant behavior of breast cancer cells. We have found that the transcriptional repressor BCL6 is highly expressed in breast cancer cell lines, and its locus is amplified in about half of primary breast cancers. To understand how BCL6 regulates gene expression in breast cancer cells, we utilized ChIP-seq to identify the BCL6 binding sites on a genomic scale. This revealed that BCL6 regulates a unique cohort of genes in breast cancer cell lines compared to B cell lymphomas. Furthermore, BCL6 expression promotes the survival of breast cancer cells, and targeting BCL6 with a peptidomimetic inhibitor leads to apoptosis of these cells. Finally, combining a BCL6 inhibitor and a STAT3 inhibitor provided enhanced cell killing in triple negative breast cancer cell lines, suggesting that combination therapy may be particularly useful. Thus, targeting BCL6 alone or in conjunction with other signaling pathways may be a useful therapeutic strategy for treating breast cancer.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/onc.2014.61en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175367/pdf/en
dash.licenseLAAen_US
dc.subjectBreast canceren
dc.subjectTranscription modulatorsen
dc.subjectTargeted therapyen
dc.subjectGene expressionen
dc.titleThe transcriptional modulator BCL6 as a molecular target for breast cancer therapyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncogeneen
dash.depositing.authorWalker, Sarah R.en_US
dc.date.available2015-09-01T13:28:09Z
dc.identifier.doi10.1038/onc.2014.61*
dash.contributor.affiliatedLiu, Suhu
dash.contributor.affiliatedFrank, David
dash.contributor.affiliatedWalker, Sarah


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