dc.contributor.author | Ok, Chi Young | en_US |
dc.contributor.author | Ye, Qing | en_US |
dc.contributor.author | Li, Ling | en_US |
dc.contributor.author | Manyam, Ganiraju C. | en_US |
dc.contributor.author | Deng, Lijuan | en_US |
dc.contributor.author | Goswami, Rashmi R. | en_US |
dc.contributor.author | Wang, Xiaoxiao | en_US |
dc.contributor.author | Montes-Moreno, Santiago | en_US |
dc.contributor.author | Visco, Carlo | en_US |
dc.contributor.author | Tzankov, Alexandar | en_US |
dc.contributor.author | Dybkaer, Karen | en_US |
dc.contributor.author | Zhang, Li | en_US |
dc.contributor.author | Abramson, Jeremy | en_US |
dc.contributor.author | Sohani, Aliyah R. | en_US |
dc.contributor.author | Chiu, April | en_US |
dc.contributor.author | Orazi, Attilio | en_US |
dc.contributor.author | Zu, Youli | en_US |
dc.contributor.author | Bhagat, Govind | en_US |
dc.contributor.author | Richards, Kristy L. | en_US |
dc.contributor.author | Hsi, Eric D. | en_US |
dc.contributor.author | Choi, William W.L. | en_US |
dc.contributor.author | van Krieken, J. Han | en_US |
dc.contributor.author | Huh, Jooryung | en_US |
dc.contributor.author | Ponzoni, Maurilio | en_US |
dc.contributor.author | Ferreri, Andrés J.M. | en_US |
dc.contributor.author | Zhang, Shanxiang | en_US |
dc.contributor.author | Parsons, Ben M. | en_US |
dc.contributor.author | Xu, Mina | en_US |
dc.contributor.author | Møller, Michael B. | en_US |
dc.contributor.author | Winter, Jane N. | en_US |
dc.contributor.author | Piris, Miguel A. | en_US |
dc.contributor.author | Xu-Monette, Zijun Y. | en_US |
dc.contributor.author | Medeiros, L. Jeffrey | en_US |
dc.contributor.author | Young, Ken H. | en_US |
dc.date.accessioned | 2015-09-01T13:28:10Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Ok, C. Y., Q. Ye, L. Li, G. C. Manyam, L. Deng, R. R. Goswami, X. Wang, et al. 2015. “Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary?” Oncotarget 6 (16): 13933-13945. | en |
dc.identifier.issn | 1949-2553 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462171 | |
dc.description.abstract | Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+ DLBCL-e) is a molecularly distinct variant of DLBCL, characterized by a monoclonal B-cell proliferation that occurs in patients >50 years of age without a history or clinicopathologic evidence of immunodeficiency. However, patients with EBV+ DLBCL younger than 50-years-old also exist in Western countries. We evaluated the clinicopathologic, immunophenotypic and genetic features in Cacausian patients with EBV+ DLBCL who are ≤50 years of age and compared this patient group to patients who are >50 years. In patients who are ≤50 years, less frequent expression of BCL6 and a trend of more frequent expression of CD30 and pSTAT3 were found in patients with EBV+ DLBCL. In patients who are >50 years, common expression of CD30, p50, pSTAT3 and less frequent expression of BCL6 were observed. Older patients also more commonly had a poor performance status (ECOG≥2). Comparing EBV+ DLBCL patients in ≤50 years versus >50 years, both groups had similar clinicopathologic, immunophenotypic and genetic features. Gene expression profiling, microRNA profiling and treatment outcome of the younger patients with EBV+ DLBCL was not distinctive from tumors in older patients. Based on our data, we suggest that the arbitrary age cutoff for EBV+ DLBCL is unnecessary and should be eliminated in the WHO lymphoma classification scheme. | en |
dc.language.iso | en_US | en |
dc.publisher | Impact Journals LLC | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546442/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | EBV | en |
dc.subject | DLBCL | en |
dc.subject | elderly | en |
dc.subject | gene expression profiling | en |
dc.title | Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary? | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Oncotarget | en |
dash.depositing.author | Abramson, Jeremy | en_US |
dc.date.available | 2015-09-01T13:28:10Z | |
dash.authorsordered | false | |
dash.contributor.affiliated | Abramson, Jeremy | |