Structure-Inherent Targeting of NIR Fluorophores for Parathyroid and Thyroid Gland Imaging
Park, Min Ho
Owens, Eric A.
Handgraaf, Hein J.M.
Vahrmeijer, Alexander L.
Choi, Hak Soo
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CitationHyun, Hoon, Min Ho Park, Eric A. Owens, Hideyuki Wada, Maged Henary, Hein J.M. Handgraaf, Alexander L. Vahrmeijer, John V. Frangioni, and Hak Soo Choi. 2014. “Structure-Inherent Targeting of NIR Fluorophores for Parathyroid and Thyroid Gland Imaging.” Nature medicine 21 (2): 192-197. doi:10.1038/nm.3728. http://dx.doi.org/10.1038/nm.3728.
AbstractThe typical method for creating targeted contrast agents requires covalent conjugation of separate targeting and fluorophore domains. In this study, we demonstrate that it is possible create tissue-specific near-infrared fluorophores using the inherent chemical structure. Thus, a single compact molecule performs both targeting and imaging. We use this strategy to solve a major problem in head/neck surgery, the identification and preservation of parathyroid and thyroid glands. We synthesized 700-nm and 800-nm halogenated fluorophores that show high uptake in the specific glands after a single intravenous injection of only 0.06 mg kg−1 in a pig. Using a dual-channel near-infrared imaging system, we demonstrate the real-time, high-sensitivity, unambiguous identification of parathyroid and thyroid glands simultaneously in the context of blood and surrounding soft tissue. This novel technology lays the foundation for head/neck surgery performed with increased precision and efficiency, and potentially lowers morbidity, and a general strategy for targeted near-infrared fluorophore development.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462236
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