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dc.contributor.authorZhang, Xuelien_US
dc.contributor.authorTian, Yanlien_US
dc.contributor.authorZhang, Hongbinen_US
dc.contributor.authorKavishwar, Amolen_US
dc.contributor.authorLynes, Matthewen_US
dc.contributor.authorBrownell, Anna-Liisaen_US
dc.contributor.authorSun, Hongbinen_US
dc.contributor.authorTseng, Yu-Huaen_US
dc.contributor.authorMoore, Annaen_US
dc.contributor.authorRan, Chongzhaoen_US
dc.date.accessioned2015-09-01T13:28:15Z
dc.date.issued2015en_US
dc.identifier.citationZhang, Xueli, Yanli Tian, Hongbin Zhang, Amol Kavishwar, Matthew Lynes, Anna-Liisa Brownell, Hongbin Sun, Yu-Hua Tseng, Anna Moore, and Chongzhao Ran. 2015. “Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.” Scientific Reports 5 (1): 13116. doi:10.1038/srep13116. http://dx.doi.org/10.1038/srep13116.en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462242
dc.description.abstractManipulation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) can be promising new approaches to counter metabolic disorder diseases in humans. Imaging probes that could consistently monitor BAT mass and browning of WAT are highly desirable. In the course of our imaging probe screening, we found that BAT could be imaged with curcumin analogues in mice. However, the poor BAT selectivity over WAT and short emissions of the lead probes promoted further lead optimization. Limited uptake mechanism studies suggested that CD36/FAT (fatty acid transporter) probably contributed to the facilitated uptake of the probes. By increasing the stereo-hindrance of the lead compound, we designed CRANAD-29 to extend the emission and increase the facilitated uptake, thus increasing its BAT selectivity. Our data demonstrated that CRANAD-29 had significantly improved selectivity for BAT over WAT, and could be used for imaging BAT mass change in a streptozotocin-induced diabetic mouse model, as well as for monitoring BAT activation under cold exposure. In addition, CRANAD-29 could be used for monitoring the browning of subcutaneous WAT (sWAT) induced by β3-adrenoceptor agonist CL-316, 243.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep13116en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534785/pdf/en
dash.licenseLAAen_US
dc.titleCurcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browningen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorLynes, Matthewen_US
dc.date.available2015-09-01T13:28:15Z
dc.identifier.doi10.1038/srep13116*
dash.authorsorderedfalse
dash.contributor.affiliatedLynes, Matthew
dash.contributor.affiliatedTseng, Yu-Hua
dash.contributor.affiliatedMoore, Anna
dash.contributor.affiliatedBrownell, Anna-Liisa
dash.contributor.affiliatedRan, Chongzhao


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