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dc.contributor.authorKissick, Haydn T.en_US
dc.contributor.authorOn, Seung T.en_US
dc.contributor.authorDunn, Laura K.en_US
dc.contributor.authorSanda, Martin G.en_US
dc.contributor.authorAsara, John M.en_US
dc.contributor.authorPellegrini, Kathryn L.en_US
dc.contributor.authorNoel, Jonathan K.en_US
dc.contributor.authorArredouani, Mohamed S.en_US
dc.date.accessioned2015-09-01T13:28:24Z
dc.date.issued2015en_US
dc.identifier.citationKissick, Haydn T., Seung T. On, Laura K. Dunn, Martin G. Sanda, John M. Asara, Kathryn L. Pellegrini, Jonathan K. Noel, and Mohamed S. Arredouani. 2015. “The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells.” BMC Cancer 15 (1): 604. doi:10.1186/s12885-015-1612-3. http://dx.doi.org/10.1186/s12885-015-1612-3.en
dc.identifier.issn1471-2407en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462379
dc.description.abstractBackground: The TMPRSS2-ERG gene fusion occurs in about half of prostate cancer (PCa) cases and results in overexpression of the transcription factor ERG. Overexpression of ERG has many effects on cellular function. However, how these changes enhance cell growth and promote tumor development is unclear. Methods: To investigate the role of ERG, LNCaP and PC3 cells were transfected with ERG and gene expression and metabolic profile were analyzed. Results: Our data show that expression of ERG induces overexpression of many nicotinicacetylcholine receptors (nAChRs). In addition, metabolic profiling by LC-MS/MS revealed elevated production of several neurotransmitters in cells expressing ERG. Consistently, treatment of ERG-expressing cells with nicotine induced elevated calcium influx, GSK3β (Ser9) phosphorylation and cell proliferation. Finally, we show that PCa patientswho are smokers have larger tumors if their tumors are TMPRSS2-ERG gene fusion positive. Conclusion: Collectively, our data suggest that ERG sensitizes prostate tumor cells to neurotransmitter receptor agonists like nicotine. Electronic supplementary material The online version of this article (doi:10.1186/s12885-015-1612-3) contains supplementary material, which is available to authorized users.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12885-015-1612-3en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549934/pdf/en
dash.licenseLAAen_US
dc.titleThe transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cellsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Canceren
dash.depositing.authorAsara, John M.en_US
dc.date.available2015-09-01T13:28:24Z
dc.identifier.doi10.1186/s12885-015-1612-3*
dash.contributor.affiliatedArredouani, Mohamed Simo
dash.contributor.affiliatedAsara, John


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