Show simple item record

dc.contributor.authorGoyette, Philippeen_US
dc.contributor.authorBoucher, Gabrielleen_US
dc.contributor.authorMallon, Dermoten_US
dc.contributor.authorEllinghaus, Evaen_US
dc.contributor.authorJostins, Lukeen_US
dc.contributor.authorHuang, Hailiangen_US
dc.contributor.authorRipke, Stephanen_US
dc.contributor.authorGusareva, Elena Sen_US
dc.contributor.authorAnnese, Vitoen_US
dc.contributor.authorHauser, Stephen Len_US
dc.contributor.authorOksenberg, Jorge Ren_US
dc.contributor.authorThomsen, Ingoen_US
dc.contributor.authorLeslie, Stephenen_US
dc.contributor.authorDaly, Mark Jen_US
dc.contributor.authorVan Steen, Kristelen_US
dc.contributor.authorDuerr, Richard Hen_US
dc.contributor.authorBarrett, Jeffrey Cen_US
dc.contributor.authorMcGovern, Dermot PBen_US
dc.contributor.authorSchumm, L Philipen_US
dc.contributor.authorTraherne, James Aen_US
dc.contributor.authorCarrington, Mary Nen_US
dc.contributor.authorKosmoliaptsis, Vasilisen_US
dc.contributor.authorKarlsen, Tom Hen_US
dc.contributor.authorFranke, Andreen_US
dc.contributor.authorRioux, John Den_US
dc.date.accessioned2015-09-01T13:28:32Z
dc.date.issued2014en_US
dc.identifier.citationGoyette, P., G. Boucher, D. Mallon, E. Ellinghaus, L. Jostins, H. Huang, S. Ripke, et al. 2014. “High density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.” Nature genetics 47 (2): 172-179. doi:10.1038/ng.3176. http://dx.doi.org/10.1038/ng.3176.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462501
dc.description.abstractGenome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn’s disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical HLA molecules1. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but lacked the statistical power to define the architecture of association and causal alleles2,3. To address this, we performed high-density SNP typing of the MHC in >32,000 patients with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn’s disease and ulcerative colitis. Significant differences were observed between these diseases, including a predominant role of class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response to the colonic environment in the pathogenesis of IBD.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.3176en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310771/pdf/en
dash.licenseLAAen_US
dc.titleHigh density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorHuang, Hailiangen_US
dc.date.available2015-09-01T13:28:32Z
dc.identifier.doi10.1038/ng.3176*
dash.authorsorderedfalse
dash.contributor.affiliatedHuang, Hailiang
dash.contributor.affiliatedRipke, Stephan
dash.contributor.affiliatedDaly, Mark


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record