No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
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CitationDo, Ron, Daniel Balick, Heng Li, Ivan Adzhubei, Shamil Sunyaev, and David Reich. 2014. “No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans.” Nature genetics 47 (2): 126-131. doi:10.1038/ng.3186. http://dx.doi.org/10.1038/ng.3186.
AbstractNon-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured the per-genome accumulation of non-synonymous substitutions across diverse pairs of populations. We find no evidence for a higher load of deleterious mutations in non-Africans. However, we detect significant differences among more divergent populations, as archaic Denisovans have accumulated non-synonymous mutations faster than either modern humans or Neanderthals. To reconcile these findings with patterns that have been interpreted as evidence of less effective removal of deleterious mutations in non-Africans than in West Africans, we use simulations to show that the observed patterns are not likely to reflect changes in the effectiveness of selection after the populations split, and instead are likely to be driven by other population genetic factors.
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