Show simple item record

dc.contributor.authorStein, Jürgenen_US
dc.contributor.authorSchuppan, Detlefen_US
dc.date.accessioned2015-09-01T13:28:42Z
dc.date.issued2014en_US
dc.identifier.citationStein, Jürgen, and Detlef Schuppan. 2014. “Coeliac Disease – New Pathophysiological Findings and Their Implications for Therapy.” Viszeralmedizin 30 (3): 156-165. doi:10.1159/000365099. http://dx.doi.org/10.1159/000365099.en
dc.identifier.issn1662-6664en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:21462648
dc.description.abstractSummary Coeliac disease (CD) is one of the most common diseases worldwide, resulting from a combination of environmental (gluten) and genetic (human leucocyte antigen (HLA) and non-HLA genes) factors. Depending on the geographical location, the prevalence of CD has been estimated to approximate 0.5-1%. The only treatment currently available for CD is a gluten-free diet (GFD) excluding gluten-containing cereals such as wheat, rye, and barley, and other foodstuffs with natural or added gluten. However, adherence rates and patient acceptance are often poor. Moreover, even in fully adherent patients, the diet may fail to induce clinical or histological improvement. Hence, it is unsurprising that studies show CD patients to be highly interested in non-dietary alternatives. The following review focuses on current pathophysiological concepts of CD, spotlighting those pathways which may serve as new possible, non-dietary therapeutic targets in the treatment of CD.en
dc.language.isoen_USen
dc.publisherS. Karger Verlag für Medizin und Naturwissenschaften GmbHen
dc.relation.isversionofdoi:10.1159/000365099en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513807/pdf/en
dash.licenseLAAen_US
dc.subjectCoeliac diseaseen
dc.subjectGluten-sensitive enteropathyen
dc.subjectMalabsorptionen
dc.subjectZonulin inhibitoren
dc.subjectTherapeutic vaccineen
dc.subjectTransglutaminase inhibitorsen
dc.titleCoeliac Disease – New Pathophysiological Findings and Their Implications for Therapyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalViszeralmedizinen
dc.date.available2015-09-01T13:28:42Z
dc.identifier.doi10.1159/000365099*


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record