Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation
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Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation
| Title: | Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation |
| Author: |
Kushibiki, Toshihiro; Tu, Yupeng; Abu-Yousif, Adnan O.; Hasan, Tayyaba
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Kushibiki, Toshihiro, Yupeng Tu, Adnan O. Abu-Yousif, and Tayyaba Hasan. 2015. “Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation.” Scientific Reports 5 (1): 13114. doi:10.1038/srep13114. http://dx.doi.org/10.1038/srep13114. |
| Full Text & Related Files: |
4538568.pdf (1.594Mb; PDF) 
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| Abstract: | In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends on the PDT dose and the nature of the photosensitizer. Although high levels of ROS are cytotoxic, at physiological levels they play a key role as second messengers in cellular signaling pathways, pluripotency, and differentiation of stem cells. To investigate further the use of photochemically triggered manipulation of such pathways, we exposed mouse osteoblast precursor cells and rat primary mesenchymal stromal cells to low-dose PDT. Our results demonstrate that low-dose PDT can promote osteoblast differentiation via the activation of activator protein-1 (AP-1). Although PDT has been used primarily as an anti-cancer therapy, the use of light as a photochemical “molecular switch” to promote differentiation should expand the utility of this method in basic research and clinical applications. |
| Published Version: | doi:10.1038/srep13114 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538568/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462658 |
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