Whole-Brain Activity Maps Reveal Stereotyped, Distributed Networks for Visuomotor Behavior

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Whole-Brain Activity Maps Reveal Stereotyped, Distributed Networks for Visuomotor Behavior

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Title: Whole-Brain Activity Maps Reveal Stereotyped, Distributed Networks for Visuomotor Behavior
Author: Portugues, Ruben; Feierstein, Claudia E; Engert, Florian; Orger, Michael B

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Citation: Portugues, Ruben, Claudia E. Feierstein, Florian Engert, and Michael B. Orger. 2014. “Whole-Brain Activity Maps Reveal Stereotyped, Distributed Networks for Visuomotor Behavior.” Neuron 81 (6) (March): 1328–1343. doi:10.1016/j.neuron.2014.01.019.
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Abstract: Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.
Published Version: doi:10.1016/j.neuron.2014.01.019
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448760/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:22543065
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