Open-Label Study of Duloxetine for the Treatment of Obsessive-Compulsive Disorder
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Corse, Andrew K.
Duffy, Amanda
Arulpragasam, Amanda R.
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https://doi.org/10.1093/ijnp/pyu062Metadata
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Dougherty, Darin D., Andrew K. Corse, Tina Chou, Amanda Duffy, Amanda R. Arulpragasam, Thilo Deckersbach, Michael A. Jenike, and Nancy J. Keuthen. 2015. “Open-Label Study of Duloxetine for the Treatment of Obsessive-Compulsive Disorder.” International Journal of Neuropsychopharmacology 18 (2): pyu062. doi:10.1093/ijnp/pyu062. http://dx.doi.org/10.1093/ijnp/pyu062.Abstract
Background: This study sought to investigate the efficacy of duloxetine for the treatment of obsessive-compulsive disorder (DSM-IV). Methods: Twenty individuals were enrolled in a 17-week, open-label trial of duloxetine at Massachusetts General Hospital. Data were collected between March 2007 and September 2012. Study measures assessing obsessive-compulsive disorder symptoms, quality of life, depression, and anxiety were administered at baseline and weeks 1, 5, 9, 13, and 17. The primary outcome measures were the Yale-Brown Obsessive Compulsive Scale and Clinical Global Improvement scale. Results: For the 12 study completers, pre- and posttreatment analyses revealed significant improvements (P<.05) on clinician- and self-rated measures of obsessive-compulsive disorder symptoms and quality of life. Among the 12 completers, more than one-half (n=7) satisfied full medication response criteria. Intention-to-treat analyses (n=20) showed similar improvements (P<.05) on primary and secondary study outcome measures. Conclusion: The results of this study suggest that duloxetine may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder. ClinicalTrials.gov NCT00464698; http://clinicaltrials.gov/ct2/show/NCT00464698?term=NCT00464698&rank=1.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368895/pdf/Terms of Use
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