Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
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Fages, Anne
Duarte-Salles, Talita
Stepien, Magdalena
Ferrari, Pietro
Fedirko, Veronika
Pontoizeau, Clément
Trichopoulou, Antonia
Aleksandrova, Krasimira
Tjønneland, Anne
Olsen, Anja
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Kaaks, Rudolf
Kuhn, Tilman
Floegel, Anna
Boeing, Heiner
Bamia, Christina
Trichopoulos, Dimitrios
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Bueno-de-Mesquita, H. Bas
Peeters, Petra H.
Weiderpass, Elisabete
Agudo, Antonio
Molina-Montes, Esther
Huerta, José María
Ardanaz, Eva
Dorronsoro, Miren
Sjöberg, Klas
Ohlsson, Bodil
Khaw, Kay-Tee
Wareham, Nick
Travis, Ruth C.
Schmidt, Julie A.
Cross, Amanda
Gunter, Marc
Riboli, Elio
Scalbert, Augustin
Romieu, Isabelle
Elena-Herrmann, Benedicte
Jenab, Mazda
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1186/s12916-015-0462-9Metadata
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Fages, A., T. Duarte-Salles, M. Stepien, P. Ferrari, V. Fedirko, C. Pontoizeau, A. Trichopoulou, et al. 2015. “Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort.” BMC Medicine 13 (1): 242. doi:10.1186/s12916-015-0462-9. http://dx.doi.org/10.1186/s12916-015-0462-9.Abstract
Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer. Electronic supplementary material The online version of this article (doi:10.1186/s12916-015-0462-9) contains supplementary material, which is available to authorized users.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581424/pdf/Terms of Use
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