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dc.contributor.authorFages, Anneen_US
dc.contributor.authorDuarte-Salles, Talitaen_US
dc.contributor.authorStepien, Magdalenaen_US
dc.contributor.authorFerrari, Pietroen_US
dc.contributor.authorFedirko, Veronikaen_US
dc.contributor.authorPontoizeau, Clémenten_US
dc.contributor.authorTrichopoulou, Antoniaen_US
dc.contributor.authorAleksandrova, Krasimiraen_US
dc.contributor.authorTjønneland, Anneen_US
dc.contributor.authorOlsen, Anjaen_US
dc.contributor.authorClavel-Chapelon, Françoiseen_US
dc.contributor.authorBoutron-Ruault, Marie-Christineen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorKaaks, Rudolfen_US
dc.contributor.authorKuhn, Tilmanen_US
dc.contributor.authorFloegel, Annaen_US
dc.contributor.authorBoeing, Heineren_US
dc.contributor.authorLagiou, Pagonaen_US
dc.contributor.authorBamia, Christinaen_US
dc.contributor.authorTrichopoulos, Dimitriosen_US
dc.contributor.authorPalli, Domenicoen_US
dc.contributor.authorPala, Valeriaen_US
dc.contributor.authorPanico, Salvatoreen_US
dc.contributor.authorTumino, Rosarioen_US
dc.contributor.authorVineis, Paoloen_US
dc.contributor.authorBueno-de-Mesquita, H. Basen_US
dc.contributor.authorPeeters, Petra H.en_US
dc.contributor.authorWeiderpass, Elisabeteen_US
dc.contributor.authorAgudo, Antonioen_US
dc.contributor.authorMolina-Montes, Estheren_US
dc.contributor.authorHuerta, José Maríaen_US
dc.contributor.authorArdanaz, Evaen_US
dc.contributor.authorDorronsoro, Mirenen_US
dc.contributor.authorSjöberg, Klasen_US
dc.contributor.authorOhlsson, Bodilen_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorWareham, Nicken_US
dc.contributor.authorTravis, Ruth C.en_US
dc.contributor.authorSchmidt, Julie A.en_US
dc.contributor.authorCross, Amandaen_US
dc.contributor.authorGunter, Marcen_US
dc.contributor.authorRiboli, Elioen_US
dc.contributor.authorScalbert, Augustinen_US
dc.contributor.authorRomieu, Isabelleen_US
dc.contributor.authorElena-Herrmann, Benedicteen_US
dc.contributor.authorJenab, Mazdaen_US
dc.date.accessioned2015-10-01T14:55:44Z
dc.date.issued2015en_US
dc.identifier.citationFages, A., T. Duarte-Salles, M. Stepien, P. Ferrari, V. Fedirko, C. Pontoizeau, A. Trichopoulou, et al. 2015. “Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort.” BMC Medicine 13 (1): 242. doi:10.1186/s12916-015-0462-9. http://dx.doi.org/10.1186/s12916-015-0462-9.en
dc.identifier.issn1741-7015en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:22856888
dc.description.abstractBackground: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer. Electronic supplementary material The online version of this article (doi:10.1186/s12916-015-0462-9) contains supplementary material, which is available to authorized users.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12916-015-0462-9en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581424/pdf/en
dash.licenseLAAen_US
dc.subjectEpidemiologyen
dc.subjectEuropean Prospective Investigation into Cancer and Nutritionen
dc.subjectHepatocellular carcinomaen
dc.subjectLiver canceren
dc.subjectMetabolomicsen
dc.subjectNuclear magnetic resonanceen
dc.titleMetabolomic profiles of hepatocellular carcinoma in a European prospective cohorten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Medicineen
dash.depositing.authorLagiou, Pagonaen_US
dc.date.available2015-10-01T14:55:44Z
dc.identifier.doi10.1186/s12916-015-0462-9*
dash.authorsorderedfalse
dash.contributor.affiliatedLagiou, Pagona


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