| dc.contributor.author | Yeung, Charles
S. | en_US |
| dc.contributor.author | Ziegler, Robert E. | en_US |
| dc.contributor.author | Porco, John A. | en_US |
| dc.contributor.author | Jacobsen, Eric N. | en_US |
| dc.date.accessioned | 2015-10-01T14:56:04Z | |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | Yeung, Charles S., Robert E. Ziegler, John A. Porco, and Eric N. Jacobsen. 2014. “Thiourea-Catalyzed Enantioselective Addition of Indoles to Pyrones: Alkaloid Cores with Quaternary Carbons.” Journal of the American Chemical Society 136 (39): 13614-13617. doi:10.1021/ja508523g. http://dx.doi.org/10.1021/ja508523g. | en |
| dc.identifier.issn | 0002-7863 | en |
| dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856910 | |
| dc.description.abstract | We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Brønsted acid. The indole–pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid natural product pleiocarpamine. | en |
| dc.language.iso | en_US | en |
| dc.publisher | American Chemical
Society | en |
| dc.relation.isversionof | doi:10.1021/ja508523g | en |
| dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235369/pdf/ | en |
| dash.license | LAA | en_US |
| dc.title | Thiourea-Catalyzed Enantioselective Addition of Indoles to Pyrones: Alkaloid Cores with Quaternary Carbons | en |
| dc.type | Journal Article | en_US |
| dc.description.version | Version of Record | en |
| dc.relation.journal | Journal of the American Chemical Society | en |
| dash.depositing.author | Jacobsen, Eric N. | en_US |
| dc.date.available | 2015-10-01T14:56:04Z | |
| dc.identifier.doi | 10.1021/ja508523g | * |
| dash.contributor.affiliated | Jacobsen, Eric | |
