Abnormal auditory and language pathways in children with 16p11.2 deletion
View/ Open
Author
Berman, Jeffrey I.
Chudnovskaya, Darina
Blaskey, Lisa
Kuschner, Emily
Mukherjee, Pratik
Buckner, Randall
Nagarajan, Srikantan
Chung, Wendy K.
Spiro, John E.
Sherr, Elliott H.
Roberts, Timothy P.L.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1016/j.nicl.2015.07.006Metadata
Show full item recordCitation
Berman, J. I., D. Chudnovskaya, L. Blaskey, E. Kuschner, P. Mukherjee, R. Buckner, S. Nagarajan, et al. 2015. “Abnormal auditory and language pathways in children with 16p11.2 deletion.” NeuroImage : Clinical 9 (1): 50-57. doi:10.1016/j.nicl.2015.07.006. http://dx.doi.org/10.1016/j.nicl.2015.07.006.Abstract
Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4–BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543079/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856925
Collections
- FAS Scholarly Articles [18256]
Contact administrator regarding this item (to report mistakes or request changes)