Biogenesis, delivery, and function of extracellular RNA

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Biogenesis, delivery, and function of extracellular RNA

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Title: Biogenesis, delivery, and function of extracellular RNA
Author: Patton, James G.; Franklin, Jeffrey L.; Weaver, Alissa M.; Vickers, Kasey; Zhang, Bing; Coffey, Robert J.; Ansel, K. Mark; Blelloch, Robert; Goga, Andrei; Huang, Bo; L'Etoille, Noelle; Raffai, Robert L.; Lai, Charles P.; Krichevsky, Anna M.; Mateescu, Bogdan; Greiner, Vanille J.; Hunter, Craig; Voinnet, Olivier; McManus, Michael T.

Note: Order does not necessarily reflect citation order of authors.

Citation: Patton, J. G., J. L. Franklin, A. M. Weaver, K. Vickers, B. Zhang, R. J. Coffey, K. M. Ansel, et al. 2015. “Biogenesis, delivery, and function of extracellular RNA.” Journal of Extracellular Vesicles 4 (1): 10.3402/jev.v4.27494. doi:10.3402/jev.v4.27494. http://dx.doi.org/10.3402/jev.v4.27494.
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Abstract: The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.
Published Version: doi:10.3402/jev.v4.27494
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553266/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856948
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