A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol
View/ Open
Author
Longo, Dario
L.
Consolino, Lorena
Michelotti, Filippo
C.
Uggeri, Fulvio
Aime, Silvio
Published Version
https://doi.org/10.1021/ja5059313Metadata
Show full item recordCitation
Longo, Dario L., Phillip Zhe Sun, Lorena Consolino, Filippo C. Michelotti, Fulvio Uggeri, and Silvio Aime. 2014. “A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Mapping with Iobitridol.” Journal of the American Chemical Society 136 (41): 14333-14336. doi:10.1021/ja5059313. http://dx.doi.org/10.1021/ja5059313.Abstract
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are transferred to MRI-detectable bulk water signal. MRI-CEST (pH)-responsive agents are probes able to map pH in the microenvironment in which they distribute. To minimize the confounding effects of contrast agent concentration, researchers have developed ratiometric CEST imaging, which investigates contrast agents containing multiple magnetically non-equivalent proton groups, whose prototropic exchange have different pH responses. However, conventional ratiometric CEST MRI imposes stringent requirements on the selection of CEST contrasts agents. In this study, a novel ratiometric pH MRI method based on the analysis of CEST effects under different radio frequency irradiation power levels was developed. The proposed method has been demonstrated using iobitridol, an X-ray contrast agent analog of iopamidol but containing a single set of amide protons, both in vitro and in vivo.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210149/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856989
Collections
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)