Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin

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Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin

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Title: Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin
Author: Durak, Omer; de Anda, Froylan Calderon; Singh, Karun K.; Leussis, Melanie P.; Petryshen, Tracey L.; Sklar, Pamela; Tsai, Li-Huei

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Citation: Durak, Omer, Froylan Calderon de Anda, Karun K. Singh, Melanie P. Leussis, Tracey L. Petryshen, Pamela Sklar, and Li-Huei Tsai. 2014. “Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin.” Molecular psychiatry 20 (3): 388-397. doi:10.1038/mp.2014.42. http://dx.doi.org/10.1038/mp.2014.42.
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Abstract: Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders such as bipolar disorder (BD), schizophrenia, and autism spectrum disorder (ASD). Here, we describe a novel role for ankyrin-G in neural progenitor proliferation in the developing cortex. We found that ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availability of β-catenin in proliferating cells. Ankyrin-G loss-of-function increases β-catenin levels in the nucleus, thereby promoting neural progenitor proliferation. Importantly, abnormalities in proliferation can be rescued by reducing Wnt pathway signaling. Together, these results suggest that ankyrin-G is required for proper brain development.
Published Version: doi:10.1038/mp.2014.42
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231016/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:22857060
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