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dc.contributor.authorMarina, Neyssaen_US
dc.contributor.authorGranowetter, Lindaen_US
dc.contributor.authorGrier, Holcombe E.en_US
dc.contributor.authorWomer, Richard B.en_US
dc.contributor.authorRandall, R. Loren_US
dc.contributor.authorMarcus, Karen J.en_US
dc.contributor.authorMcIlvaine, Elizabethen_US
dc.contributor.authorKrailo, Marken_US
dc.date.accessioned2015-11-03T15:57:24Z
dc.date.issued2015en_US
dc.identifier.citationMarina, Neyssa, Linda Granowetter, Holcombe E. Grier, Richard B. Womer, R. Lor Randall, Karen J. Marcus, Elizabeth McIlvaine, and Mark Krailo. 2015. “Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report.” Sarcoma 2015 (1): 927123. doi:10.1155/2015/927123. http://dx.doi.org/10.1155/2015/927123.en
dc.identifier.issn1357-714Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23473867
dc.description.abstractPurpose. To associate baseline patient characteristics and relapse across consecutive COG studies. Methods:. We analyzed risk factors for LESFT patients in three randomized COG trials. We evaluated age at enrollment, primary site, gender, tumor size, and treatment (as randomized). We estimated event-free survival (EFS, Kaplan-Meier) and compared risk across groups (log-rank test). Characteristics were assessed by proportional hazards regression with the characteristic of interest as the only component. Confidence intervals (CI) for RR were derived. Factors related to outcome at level 0.05 were included in a multivariate regression model. Results:. Between 12/1988 and 8/2005, 1444 patients were enrolled and data current to 2001, 2004, or 2008 were used. Patients were with a median age of 12 years (0–45), 55% male and 88% Caucasian. The 5-year EFS was 68.3% ± 1.3%. In univariate analysis age, treatment, and tumor location were identified for inclusion in the multivariate model, and all remained significant (p < 0.01). Since tumor size was not collected in the last study, the other two were reanalyzed. This model identified age, treatment, tumor location, and tumor size as significant predictors. Conclusion:. Age > 18 years, pelvic tumor, size > 8 cms, and chemotherapy without ifosfamide/etoposide significantly predict worse outcome. AEWS0031 is NCT00006734, INT0091 and INT0054 designed before 1993 (unregistered).en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2015/927123en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609872/pdf/en
dash.licenseLAAen_US
dc.titleAge, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Reporten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalSarcomaen
dash.depositing.authorMarcus, Karen J.en_US
dc.date.available2015-11-03T15:57:24Z
dc.identifier.doi10.1155/2015/927123*
dash.contributor.affiliatedMarcus, Karen


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