Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease

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Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease

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Title: Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease
Author: Orban, Pierre; Madjar, Cécile; Savard, Mélissa; Dansereau, Christian; Tam, Angela; Das, Samir; Evans, Alan C.; Rosa-Neto, Pedro; Breitner, John C.S.; Bellec, Pierre; Aisen, Paul; Pascoal, Tharick Ali; Anthal, Elena; Appleby, Melissa; Barkun, Alan; Beaudry, Thomas; Benbouhoud, Fatiha; Bohbot, Veronique; Brandt, Jason; Breitner, John C. S.; Brunelle, Céline; Carmo, Leopoldina; Cheewakriengkrai, Laksanaun; Collins, Louis; Courcot, Blandine; Couture, Doris; Craft, Suzanne; Cuello, A. Claudio; Dadar, Mahsa; Dauar-Tedeschi, Marina; Dea, Dorothy; Debacker, Clément; Desautels, René; Desrochers, Nicole; Dubuc, Sylvie; Duclair, Guerda; Dufour, Marianne; Eisenberg, Mark; El-Khoury, Rana; Etienne, Pierre; Faubert, Anne Marie; Ferdinand, Fabiola; Fonov, Vladimir S.; Fontaine, David; Francoeur, Renaud; Frappier, Josée; Frenette, Joanne; Gauthier, Serge; Gervais, Valérie; Giles, Renuka; Gordon, Renee; Hoge, Rick; Hyman, Bradley T.; Iturria-Medina, Yasser; Jack, Clifford R.; Kat, Justin; Khachaturian, Zaven S.; Kliegman, Stephanie; Knopman, David S.; Kostopoulos, Penelope; Labonté, Anne; Lafaille-Magnan, Marie-Elyse; Lee, Tanya; Lepage, Claude; Leppert, Ilana; Leoutsakos, Jeannie-Marie; Mahar, Laura; Maltais, Jean-Robert; Mathieu, Axel; Mathotaarachchi, Sulantha; Maultaup, Gerhard; Mayrand, Ginette; Michaud, Diane; Miron, Justin; Montine, Thomas J.; Morris, John C.; Münter, Lisa-Marie; Nair, Vasavan; Near, Jamie; Newbold-Fox, Holly; Pagé, Véronique; Petkova, Mirela; Picard, Cynthia; Pogossova, Galina; Poirier, Isabelle; Poirier, Judes; Pruessner, Jens; Rajah, Natasha; Rioux, Pierre; Sager, Mark A.; Sperling, Reisa A.; Tariot, Pierre N.; Teigner, Eduard; Théroux, Louise; Thomas, Ronald G.; Toussaint, Paule-Joanne; Tremblay-Mercier, Jennifer; Tuwaig, Miranda; Vallée, Isabelle; Venogopalan, Vinod; Wan, Karen; Wang, Seqian

Note: Order does not necessarily reflect citation order of authors.

Citation: Orban, P., C. Madjar, M. Savard, C. Dansereau, A. Tam, S. Das, A. C. Evans, et al. 2015. “Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease.” Scientific Data 2 (1): 150043. doi:10.1038/sdata.2015.43. http://dx.doi.org/10.1038/sdata.2015.43.
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Abstract: We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the “Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease” (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.
Published Version: doi:10.1038/sdata.2015.43
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603392/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23473885
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