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dc.contributor.authorTabas, Iraen_US
dc.contributor.authorGarcía-Cardeña, Guillermoen_US
dc.contributor.authorOwens, Gary K.en_US
dc.date.accessioned2015-11-03T15:57:34Z
dc.date.issued2015en_US
dc.identifier.citationTabas, Ira, Guillermo García-Cardeña, and Gary K. Owens. 2015. “Recent insights into the cellular biology of atherosclerosis.” The Journal of Cell Biology 209 (1): 13-22. doi:10.1083/jcb.201412052. http://dx.doi.org/10.1083/jcb.201412052.en
dc.identifier.issn0021-9525en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23473888
dc.description.abstractAtherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein retention. Over time, this process stimulates a nonresolving inflammatory response that can cause intimal destruction, arterial thrombosis, and end-organ ischemia. Recent advances highlight important cell biological atherogenic processes, including mechanotransduction and inflammatory processes in endothelial cells, origins and contributions of lesional macrophages, and origins and phenotypic switching of lesional smooth muscle cells. These advances illustrate how in-depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas for therapy.en
dc.language.isoen_USen
dc.publisherThe Rockefeller University Pressen
dc.relation.isversionofdoi:10.1083/jcb.201412052en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395483/pdf/en
dash.licenseLAAen_US
dc.subjectReviewen
dc.titleRecent insights into the cellular biology of atherosclerosisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalThe Journal of Cell Biologyen
dash.depositing.authorGarcía-Cardeña, Guillermoen_US
dc.date.available2015-11-03T15:57:34Z
dc.identifier.doi10.1083/jcb.201412052*
dash.contributor.affiliatedGarcia-Cardena, Guillermo


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