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dc.contributor.authorLow, Darenen_US
dc.contributor.authorDeGruttola, Arianna K.en_US
dc.contributor.authorPoltrak, Alexanderen_US
dc.contributor.authorMizoguchi, Atsushien_US
dc.contributor.authorMino-Kenudson, Marien_US
dc.contributor.authorMizoguchi, Emikoen_US
dc.date.accessioned2015-11-03T15:57:42Z
dc.date.issued2015en_US
dc.identifier.citationLow, Daren, Arianna K. DeGruttola, Alexander Poltrak, Atsushi Mizoguchi, Mari Mino-Kenudson, and Emiko Mizoguchi. 2015. “High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice.” PLoS ONE 10 (10): e0139149. doi:10.1371/journal.pone.0139149. http://dx.doi.org/10.1371/journal.pone.0139149.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23473909
dc.description.abstractColorectal cancer (CRC) development is mediated by uncontrolled survival and proliferation of tumor progenitor cells. Using animal models to identify and study host-derived factors that underlie this process can aid interventions in preventing tumor expansion and metastasis. In healthy steady states in humans and mice (e.g. C57BL/6 strain), colonic Chitinase 3-like 1 (CHI3L1) gene expression is undetectable. However, this expression can be induced during intestinal inflammation and tumorigenesis where CHI3L1 plays an important role in tissue restitution and cell proliferation. Here, we show that a wild-derived mouse strain MOLF/EiJ expresses high levels of colonic epithelial CHI3L1 at the steady state due to several nucleotide polymorphisms in the proximal promoter regions of the CHI3L1 gene. Interestingly, these mice spontaneously developed polypoid nodules in the colon with signs of immune cell infiltrations at steady state. The CHI3L1 positive colonic epithelial cells were highly proliferative and exhibited malignant transformation and expansion when exposed in vivo to azoxymethane, one of the well-known colonic carcinogens.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0139149en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594921/pdf/en
dash.licenseLAAen_US
dc.titleHigh Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorMino-Kenudson, Marien_US
dc.date.available2015-11-03T15:57:42Z
dc.identifier.doi10.1371/journal.pone.0139149*
dash.authorsorderedfalse
dash.contributor.affiliatedMizoguchi, Emiko
dash.contributor.affiliatedMino-Kenudson, Mari


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