A Circuit Mechanism for Differentiating Positive and Negative Associations

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A Circuit Mechanism for Differentiating Positive and Negative Associations

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Title: A Circuit Mechanism for Differentiating Positive and Negative Associations
Author: Namburi, Praneeth; Beyeler, Anna; Yorozu, Suzuko; Calhoon, Gwendolyn G.; Halbert, Sarah A.; Wichmann, Romy; Holden, Stephanie S.; Mertens, Kim L.; Anahtar, Melodi; Felix-Ortiz, Ada C.; Wickersham, Ian R.; Gray, Jesse M.; Tye, Kay M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Namburi, P., A. Beyeler, S. Yorozu, G. G. Calhoon, S. A. Halbert, R. Wichmann, S. S. Holden, et al. 2015. “A Circuit Mechanism for Differentiating Positive and Negative Associations.” Nature 520 (7549): 675-678. doi:10.1038/nature14366. http://dx.doi.org/10.1038/nature14366.
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Abstract: The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive1,2 and negative3–7. Different populations of BLA neurons may encode fearful or rewarding associations8–10, but the identifying features of these populations and the synaptic mechanisms of differentiating positive and negative emotional valence have remained an enigma. Here, we show that BLA neurons projecting to the nucleus accumbens (NAc projectors) or the centromedial amygdala (CeM projectors) underwent opposing synaptic changes following fear or reward conditioning. We found that photostimulation of NAc projectors supports positive reinforcement while photostimulation of CeM projectors mediates negative reinforcement. Photoinhibition of CeM projectors impaired fear conditioning and enhanced reward conditioning. We then characterized these functionally-distinct neuronal populations by comparing their electrophysiological, morphological and genetic features. We provide a mechanistic explanation for the representation of positive and negative associations within the amygdala.
Published Version: doi:10.1038/nature14366
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418228/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23473923
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